PMID- 1829167
OWN - NLM
STAT- MEDLINE
DCOM- 19910730
LR  - 20161209
IS  - 0755-4982 (Print)
IS  - 0755-4982 (Linking)
VI  - 20
IP  - 17
DP  - 1991 May 4
TI  - [Mechanism of parathyroid cell proliferation in primary hyperparathyroidism].
PG  - 803-8
AB  - In primary hyperparathyroidism molecular biology techniques applied to the 
      pathological parathyroid tissue have shown that cell proliferation is monoclonal 
      in many sporadic adenomas and in the largest parathyroid glands of multiple 
      endocrine neoplasia type 1 (MEN-1). On the other hand, monoclonality has not been 
      found in sporadic hyperplasia and in the smaller parathyroid glands of MEN-1. In 
      addition, abnormalities have been observed in chromosome 11 which contains the 
      parathyroid hormone (PTH) gene and the MEN-1 associated gene. The PTH gene was 
      rearranged in sporadic adenomas, and there was a varying degree of chromosome 11 
      allele delection in sporadic adenomas and in MEN-1. The relationship between 
      these abnormalities and parathyroid cell proliferation is controverted, and 
      further studies are required to determine their exact role in the development of 
      primary hyperparathyroidism.
FAU - Baglin, A
AU  - Baglin A
AD  - Service de Medecine interne et Nephrologie, Hopital Ambroise-Pare 
      Boulogne-Billancourt.
FAU - Junien, C
AU  - Junien C
FAU - Prinseau, J
AU  - Prinseau J
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Mecanisme de la proliferation des cellules parathyroidiennes dans les 
      hyperparathyroidies primaires.
PL  - France
TA  - Presse Med
JT  - Presse medicale (Paris, France : 1983)
JID - 8302490
SB  - IM
MH  - Cell Division/physiology
MH  - Chromosome Aberrations/genetics
MH  - Chromosome Disorders
MH  - Chromosomes, Human, Pair 11
MH  - Clone Cells/pathology
MH  - Humans
MH  - Hyperparathyroidism/genetics/*pathology
MH  - Parathyroid Glands/*pathology
RF  - 15
EDAT- 1991/05/04 00:00
MHDA- 1991/05/04 00:01
CRDT- 1991/05/04 00:00
PHST- 1991/05/04 00:00 [pubmed]
PHST- 1991/05/04 00:01 [medline]
PHST- 1991/05/04 00:00 [entrez]
PST - ppublish
SO  - Presse Med. 1991 May 4;20(17):803-8.