PMID- 18291721
OWN - NLM
STAT- MEDLINE
DCOM- 20080722
LR  - 20080319
IS  - 1471-4892 (Print)
IS  - 1471-4892 (Linking)
VI  - 8
IP  - 2
DP  - 2008 Apr
TI  - Heart regeneration: what cells to use and how?
PG  - 211-8
LID - 10.1016/j.coph.2008.01.001 [doi]
AB  - Coronary artery disease (CAD) is the leading cause of death in modern societies. 
      Recent achievements in the treatment of CAD including statins, ACE inhibitors, 
      beta blockers, and interventional procedure improved the outcome of patients with 
      CAD, but this conventional approach failed to control cardiovascular mortality. 
      Nowadays, cells (stem cells) and their potential role in managing patients with 
      heart disease is a field of intensive research. Various types of cells have been 
      used for transplantation targeting heart regeneration, including bone marrow 
      cells (BMCs), cardiac stem cells (CSCs), endothelial progenitor cells (EPCs), 
      skeletal myoblasts (SMs), adipose stroma tissue cells (ATSCs), mesenchymal cells 
      (MCs), and embryonic stem cells (ESCs). Several routes have been used to deliver 
      these cells to human myocardium or to the coronary circulation such as, 
      intracoronary injection, intravenous infusion, direct injection into the 
      ventricular wall, or transepicardial/transendocardial infusions. Although the 
      results of the recent clinical trials in this area are rather conflicting, these 
      therapeutic approaches seem to be promising for the treatment of ischemic heart 
      disease.
FAU - Tousoulis, Dimitris
AU  - Tousoulis D
AD  - A' Cardiology Department, Athens University Medical School, Athens, Greece. 
      drtousoulis@hotmail.com
FAU - Briasoulis, Alexandros
AU  - Briasoulis A
FAU - Antoniades, Charalambos
AU  - Antoniades C
FAU - Stefanadi, Elli
AU  - Stefanadi E
FAU - Stefanadis, Christodoulos
AU  - Stefanadis C
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20080304
PL  - England
TA  - Curr Opin Pharmacol
JT  - Current opinion in pharmacology
JID - 100966133
SB  - IM
MH  - Animals
MH  - Bone Marrow Transplantation/methods
MH  - Clinical Trials as Topic
MH  - Coronary Artery Disease/physiopathology/*therapy
MH  - Humans
MH  - Injections
MH  - Myocytes, Cardiac/*metabolism/pathology
MH  - Regeneration
MH  - Stem Cell Transplantation/*methods
MH  - Stem Cells/physiology
RF  - 47
EDAT- 2008/02/23 09:00
MHDA- 2008/07/23 09:00
CRDT- 2008/02/23 09:00
PHST- 2007/10/07 00:00 [received]
PHST- 2007/12/23 00:00 [revised]
PHST- 2008/01/03 00:00 [accepted]
PHST- 2008/02/23 09:00 [pubmed]
PHST- 2008/07/23 09:00 [medline]
PHST- 2008/02/23 09:00 [entrez]
AID - S1471-4892(08)00002-7 [pii]
AID - 10.1016/j.coph.2008.01.001 [doi]
PST - ppublish
SO  - Curr Opin Pharmacol. 2008 Apr;8(2):211-8. doi: 10.1016/j.coph.2008.01.001. Epub 
      2008 Mar 4.