PMID- 18292850
OWN - NLM
STAT- MEDLINE
DCOM- 20080617
LR  - 20211020
IS  - 1198-2241 (Print)
IS  - 1916-7245 (Electronic)
IS  - 1198-2241 (Linking)
VI  - 15
IP  - 1
DP  - 2008 Jan-Feb
TI  - The CASE survey: patient and physician perceptions regarding asthma medication 
      use and associated oropharyngeal symptoms.
PG  - 27-32
AB  - BACKGROUND: Oropharyngeal (OP) symptoms are common in asthma patients using 
      inhaled corticosteroids (ICSs) alone and in combination with a long-acting 
      beta(2)-agonist (LABA). Patterns of medication use, level of asthma control and 
      association with OP symptoms are not often reported in a nonstudy setting. 
      OBJECTIVES: To determine the prevalence of OP symptoms among adult asthma 
      patients using ICSs alone and an ICS plus a LABA; to investigate the 
      relationships between medication use, asthma control and OP symptoms; and to 
      assess family physicians' (FPs') perceptions of the prevalence and management of 
      OP symptoms. METHODS: A random telephone survey of 1003 asthma patients and 250 
      FPs treating asthma patients was conducted from February to March 2005 across 
      Canada. RESULTS: Twenty-four per cent of patients experienced OP symptoms; 67% of 
      them spoke to their FPs about the OP symptoms. Thirty-one per cent of patients 
      who experienced OP symptoms stopped or reduced their dose of medication. OP 
      symptoms were reported by 25% of patients using ICSs and 22% using an ICS plus a 
      LABA. The incidence of OP symptoms was not affected by the choice of inhalation 
      device (metered-dose inhaler versus dry powder inhaler) or the use of a spacer. 
      Fifty-eight per cent of patients had uncontrolled asthma; patients achieving a 
      lower level of general education were more likely to have poor control. Patients 
      with uncontrolled asthma were more likely than those with controlled asthma to 
      report OP symptoms (28% versus 18%, respectively; P<0.05). Eighty-nine per cent 
      of FPs had patients who had reported OP symptoms to them. FPs estimated that 15% 
      of their patients experienced OP symptoms and that compliance to treatment 
      worsened in approximately 20% of them. CONCLUSIONS: The prevalence of OP symptoms 
      in asthma patients using ICSs and an ICS plus a LABA is significant. OP symptoms 
      were found to be associated with a reduced patient education level, with a 
      likelihood of reducing or stopping medication, and with a less well-controlled 
      asthma patient. While FPs recognized that a significant proportion of their 
      asthma patients experience OP symptoms and that OP symptoms may affect 
      compliance, they underestimated the prevalence of this problem.
FAU - Fitzgerald, J M
AU  - Fitzgerald JM
AD  - University of British Columbia, Vancouver, Canada. markf@interchange.ubc.ca
FAU - Chan, C Kn
AU  - Chan CK
FAU - Holroyde, M C
AU  - Holroyde MC
FAU - Boulet, Louis-Philippe
AU  - Boulet LP
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Egypt
TA  - Can Respir J
JT  - Canadian respiratory journal
JID - 9433332
RN  - 0 (Adrenergic beta-Agonists)
RN  - 0 (Glucocorticoids)
SB  - IM
MH  - Adrenergic beta-Agonists/administration & dosage/*adverse effects
MH  - Adult
MH  - Asthma/*drug therapy
MH  - Female
MH  - Glucocorticoids/administration & dosage/*adverse effects
MH  - Health Surveys
MH  - Humans
MH  - Male
MH  - Oropharynx/*drug effects
MH  - Prevalence
MH  - Treatment Outcome
PMC - PMC2677852
EDAT- 2008/02/23 09:00
MHDA- 2008/06/18 09:00
PMCR- 2009/01/01
CRDT- 2008/02/23 09:00
PHST- 2008/02/23 09:00 [pubmed]
PHST- 2008/06/18 09:00 [medline]
PHST- 2008/02/23 09:00 [entrez]
PHST- 2009/01/01 00:00 [pmc-release]
AID - crj15027 [pii]
AID - 10.1155/2008/593723 [doi]
PST - ppublish
SO  - Can Respir J. 2008 Jan-Feb;15(1):27-32. doi: 10.1155/2008/593723.