PMID- 18293109
OWN - NLM
STAT- MEDLINE
DCOM- 20080507
LR  - 20211020
IS  - 0967-3849 (Print)
IS  - 0967-3849 (Linking)
VI  - 16
IP  - 1
DP  - 2008
TI  - Evolutionarily conserved cytogenetic changes in hematological malignancies of 
      dogs and humans--man and his best friend share more than companionship.
PG  - 145-54
LID - 10.1007/s10577-007-1212-4 [doi]
AB  - The pathophysiological similarities shared by many forms of human and canine 
      disease, combined with the sophisticated genomic resources now available for the 
      dog, have placed 'man's best friend' in a position of high visibility as a model 
      system for a variety of biomedical concerns, including cancer. The importance of 
      nonrandom cytogenetic abnormalities in human leukemia and lymphoma was recognized 
      over 40 years ago, but the mechanisms of genome reorganization remain 
      incompletely understood. The development of molecular cytogenetics, using 
      fluorescence in situ hybridization (FISH) technology, has played a significant 
      role in our understanding of cancer biology by providing a means for 
      'interrogating' tumor cells for a variety of gross genetic changes in the form of 
      either numerical or structural chromosome aberrations. Here, we have identified 
      cytogenetic abnormalities in naturally occurring canine hematopoietic tumors that 
      are evolutionarily conserved compared with those that are considered 
      characteristic of the corresponding human condition. These data suggest that 
      humans and dogs share an ancestrally retained pathogenetic basis for cancer and 
      that cytogenetic evaluation of canine tumors may provide greater insight into the 
      biology of tumorigenesis.
FAU - Breen, Matthew
AU  - Breen M
AD  - Department of Molecular Biomedical Sciences, North Carolina State University, 
      Raleigh, NC, 27606, USA. Matthew_Breen@ncsu.edu
FAU - Modiano, Jaime F
AU  - Modiano JF
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Chromosome Res
JT  - Chromosome research : an international journal on the molecular, supramolecular 
      and evolutionary aspects of chromosome biology
JID - 9313452
SB  - IM
MH  - Animals
MH  - *Chromosome Aberrations
MH  - Conserved Sequence
MH  - Cytogenetics
MH  - Dogs
MH  - *Evolution, Molecular
MH  - Hematologic Neoplasms/*genetics
MH  - Humans
MH  - Male
MH  - Synteny/genetics
MH  - Translocation, Genetic
EDAT- 2008/02/23 09:00
MHDA- 2008/05/08 09:00
CRDT- 2008/02/23 09:00
PHST- 2008/02/23 09:00 [pubmed]
PHST- 2008/05/08 09:00 [medline]
PHST- 2008/02/23 09:00 [entrez]
AID - 10.1007/s10577-007-1212-4 [doi]
PST - ppublish
SO  - Chromosome Res. 2008;16(1):145-54. doi: 10.1007/s10577-007-1212-4.