PMID- 1829327
OWN - NLM
STAT- MEDLINE
DCOM- 19910730
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 260
IP  - 6 Pt 1
DP  - 1991 Jun
TI  - Effect of increased carbohydrate utilization potential on cardiac isomyosin in 
      thyroidectomized rats.
PG  - E920-6
AB  - Previous studies have shown that dietary carbohydrate (CHO) can impact on cardiac 
      isomyosin expression in hormonally deficient animals. The primary objective of 
      this study was to determine whether a high-CHO diet alters cardiac isomyosin 
      expression in severe thyroid-deficient rats. Also the effects of targeting the 
      heart with episodes of biasing cardiac metabolism toward CHO were studied. Female 
      Sprague-Dawley rats were assigned to one of two major groups: 1) normal control 
      and 2) thyroidectomized (TX) propylthiouracil treated. The TX rats were allocated 
      into four experimental subgroups as follows: 1) mixed diet; 2) high-CHO diet; 3) 
      high-CHO diet and treated with oxfenicine, a fatty acid oxidation inhibitor; and 
      4) high-CHO diet, treated with oxfenicine, and trained. Results show that, at the 
      end of 12 wk of thyroidectomy, there was a marked shift in cardiac isomyosin 
      distribution to predominance of the V3 isoform. However, 6 wk of experimental 
      manipulation failed to redirect cardiac isomyosin expression in TX rats. It is 
      concluded that increased CHO utilization does not influence cardiac isoenzyme 
      expression in markedly hypothyroid female rats. Dietary effects of CHO on cardiac 
      isomyosin require some critical level of thyroid hormone for mediating the 
      response.
FAU - Haddad, F
AU  - Haddad F
AD  - Department of Physiology and Biophysics, University of California, Irvine 92717.
FAU - Baldwin, K M
AU  - Baldwin KM
LA  - eng
GR  - R01 HL-38819/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Isoenzymes)
RN  - 0 (Liver Glycogen)
RN  - 7UYG7X0F53 (4-hydroxyphenylglycine)
RN  - 9005-79-2 (Glycogen)
RN  - EC 1.1.1.- (3-Hydroxyacyl CoA Dehydrogenases)
RN  - EC 2.3.3.1 (Citrate (si)-Synthase)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 3.6.4.1 (Myosins)
RN  - TE7660XO1C (Glycine)
SB  - IM
MH  - 3-Hydroxyacyl CoA Dehydrogenases/metabolism
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Body Weight
MH  - Citrate (si)-Synthase/metabolism
MH  - Dietary Carbohydrates/*pharmacology
MH  - Female
MH  - Glycine/analogs & derivatives/pharmacology
MH  - Glycogen/metabolism
MH  - Heart/anatomy & histology/drug effects
MH  - Hexokinase/metabolism
MH  - Isoenzymes/*metabolism
MH  - Liver Glycogen/metabolism
MH  - Muscles/enzymology
MH  - Myocardium/*enzymology
MH  - Myofibrils/enzymology
MH  - Myosins/*metabolism
MH  - Organ Size
MH  - Physical Exertion
MH  - Rats
MH  - Rats, Inbred Strains
MH  - *Thyroidectomy
EDAT- 1991/06/01 00:00
MHDA- 1991/06/01 00:01
CRDT- 1991/06/01 00:00
PHST- 1991/06/01 00:00 [pubmed]
PHST- 1991/06/01 00:01 [medline]
PHST- 1991/06/01 00:00 [entrez]
AID - 10.1152/ajpendo.1991.260.6.E920 [doi]
PST - ppublish
SO  - Am J Physiol. 1991 Jun;260(6 Pt 1):E920-6. doi: 10.1152/ajpendo.1991.260.6.E920.