PMID- 1829337
OWN - NLM
STAT- MEDLINE
DCOM- 19910801
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 260
IP  - 6 Pt 2
DP  - 1991 Jun
TI  - Interactions between ANP and ANG II in regulating blood pressure and sympathetic 
      outflow.
PG  - R1145-51
AB  - In anesthetized rats with sinoaortic denervation, intracerebroventricular (icv) 
      injection of atrial natriuretic peptide (ANP) resulted in decreased mean arterial 
      blood pressure (MAP), heart rate (HR), and renal sympathetic nerve activity 
      (RSNA) (depressor effects), whereas icv angiotensin II (ANG II) produced 
      increases in these variables (pressor effects). The depressor effects of ANP were 
      slower in onset and longer in duration than the pressor effects of ANG II. 
      Intracerebroventricular injection of the ANG II-receptor blocker sarthran or the 
      ANG II-synthesis inhibitor captopril resulted in a significant reduction in MAP; 
      HR and RSNA were not affected. Both sarthran and captopril abolished the 
      depressor responses to icv ANP. In contrast, injection of an anti-rat ANP 
      antibody, which blocked the depressor effects of icv ANP, did not by itself 
      modify MAP, HR, or RSNA, nor did the antibody affect the pressor responses to icv 
      ANG II. These data suggest that, in this animal model, the depressor effects of 
      icv ANP are mediated by the inhibition of brain ANG II-dependent neural activity. 
      These results also demonstrate that, in this preparation, the endogenous ANG II 
      system actively contributes to the maintenance of basal MAP, whereas the central 
      ANP system, at least in regions accessible to the antirat ANP antibody, plays 
      little role in this maintenance.
FAU - Steele, M K
AU  - Steele MK
AD  - Department of Physiology, University of California, San Francisco 94143-0444.
FAU - Gardner, D G
AU  - Gardner DG
FAU - Xie, P L
AU  - Xie PL
FAU - Schultz, H D
AU  - Schultz HD
LA  - eng
GR  - HL-29714/HL/NHLBI NIH HHS/United States
GR  - HL-33797/HL/NHLBI NIH HHS/United States
GR  - HL-35753/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Antibodies)
RN  - 11128-99-7 (Angiotensin II)
RN  - 56832-47-4 (angiotensin II, Sar(1)-Thr(8)-)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
RN  - 9G64RSX1XD (Captopril)
SB  - IM
MH  - Angiotensin II/analogs & derivatives/antagonists & 
      inhibitors/metabolism/pharmacology/*physiology
MH  - Animals
MH  - Antibodies/immunology
MH  - Atrial Natriuretic Factor/immunology/metabolism/*physiology
MH  - Blood Pressure/drug effects/*physiology
MH  - Captopril/pharmacology
MH  - Female
MH  - Heart Rate/drug effects/physiology
MH  - Injections, Intraventricular
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Sympathetic Nervous System/drug effects/*physiology
EDAT- 1991/06/01 00:00
MHDA- 1991/06/01 00:01
CRDT- 1991/06/01 00:00
PHST- 1991/06/01 00:00 [pubmed]
PHST- 1991/06/01 00:01 [medline]
PHST- 1991/06/01 00:00 [entrez]
AID - 10.1152/ajpregu.1991.260.6.R1145 [doi]
PST - ppublish
SO  - Am J Physiol. 1991 Jun;260(6 Pt 2):R1145-51. doi: 
      10.1152/ajpregu.1991.260.6.R1145.