PMID- 18293707
OWN - NLM
STAT- MEDLINE
DCOM- 20080623
LR  - 20131121
IS  - 0048-7848 (Print)
IS  - 0048-7848 (Linking)
VI  - 111
IP  - 3
DP  - 2007 Jul-Sep
TI  - [Visual evoked potentials in the in evaluation of the safety profile of 
      levocetirizine].
PG  - 722-8
AB  - Because human histamine H1 receptors were visualized at different brain levels, 
      we evaluated the effects of levocetirizine (LCZ) on the visual evoked potentials 
      (VEP). MATERIAL AND METHOD: Eighteen volunteer subjects were included in a 
      placebo-controlled study, VEP recordings (pattern-reversal technique) were 
      performed at baseline and 240 min. post-medication, and the N75-P100-N135 complex 
      parameters (latency, duration, amplitude and surface of the components) were 
      measured in the leads FzOL5, FzOz and FzOR5. RESULTS: LCZ 5 mg p.o. induced no 
      statistically significant changes, neither in the mean values of all P100 
      parameters, nor in the mean latency of N75 and N135 components. No unilateral or 
      bilateral alterations of VEP parameters were detected, suggesting that LCZ has no 
      influence on the functional integrity of visual sensorial pathway. CONCLUSION: 
      Our study may initiate a novel approach in the neurological safety profile 
      evaluation of new H, antihistamines using VEP, with the advantage of no 
      radiological exposure.
FAU - Popescu, Florica
AU  - Popescu F
AD  - Universitatea de Medicina si Farmacie Craiova, Facultatea de Medicini, Disciplina 
      de Farmacologie.
FAU - Popescu, F D
AU  - Popescu FD
FAU - Iancau, Maria
AU  - Iancau M
FAU - Georgescu, D
AU  - Georgescu D
LA  - rum
PT  - Controlled Clinical Trial
PT  - English Abstract
PT  - Journal Article
TT  - Potentiale evocate vizual in evaluarea profilului de siguranta al 
      levocetirizinei.
PL  - Romania
TA  - Rev Med Chir Soc Med Nat Iasi
JT  - Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi
JID - 0413735
RN  - 0 (Histamine H1 Antagonists, Non-Sedating)
RN  - 0 (Piperazines)
RN  - 6U5EA9RT2O (levocetirizine)
RN  - YO7261ME24 (Cetirizine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Algorithms
MH  - Cetirizine/*adverse effects
MH  - Double-Blind Method
MH  - *Evoked Potentials, Visual/drug effects
MH  - Female
MH  - Histamine H1 Antagonists, Non-Sedating/*adverse effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Piperazines/*adverse effects
MH  - Reaction Time
MH  - Romania
MH  - Visual Pathways/drug effects
EDAT- 2008/02/26 09:00
MHDA- 2008/06/24 09:00
CRDT- 2008/02/26 09:00
PHST- 2008/02/26 09:00 [pubmed]
PHST- 2008/06/24 09:00 [medline]
PHST- 2008/02/26 09:00 [entrez]
PST - ppublish
SO  - Rev Med Chir Soc Med Nat Iasi. 2007 Jul-Sep;111(3):722-8.