PMID- 1829411
OWN - NLM
STAT- MEDLINE
DCOM- 19910805
LR  - 20061115
IS  - 0014-2980 (Print)
IS  - 0014-2980 (Linking)
VI  - 21
IP  - 7
DP  - 1991 Jul
TI  - Induction of the interleukin 1 receptor antagonist protein by transforming growth 
      factor-beta.
PG  - 1635-9
AB  - Transforming growth factor-beta 1 (TGF-beta 1) mediates many immunosuppressive 
      effects on immune cells and can inhibit the production of tumor necrosis factor 
      and interleukin 1 (IL 1). However, TGF-beta 1 can stimulate the production of IL 
      6 and platelet-derived growth factor, indicating that TGF-beta 1 initiates 
      complex effects on the production of cytokines. In this report we show that 
      treatment of peripheral blood monocytes with TGF-beta 1 leads to the induction of 
      a recently described IL 1 receptor antagonist protein (IRAP). The effect of 
      TGF-beta 1 was both dose and time dependent. TGF-beta 1 induced de novo synthesis 
      of IRAP, as Northern blotting experiments indicated a rapid and transient 
      induction of the mRNA encoding IRAP. The induction of IRAP suggests a potential 
      mechanism by which some of the inhibitory effects of TGF-beta 1 are mediated.
FAU - Turner, M
AU  - Turner M
AD  - Charing Cross Sunley Research Centre, Hammersmith Laboratory, Kalamazoo, London, 
      GB.
FAU - Chantry, D
AU  - Chantry D
FAU - Katsikis, P
AU  - Katsikis P
FAU - Berger, A
AU  - Berger A
FAU - Brennan, F M
AU  - Brennan FM
FAU - Feldmann, M
AU  - Feldmann M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (IL1RN protein, human)
RN  - 0 (Interleukin 1 Receptor Antagonist Protein)
RN  - 0 (Interleukin-1)
RN  - 0 (Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Sialoglycoproteins)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Cells, Cultured
MH  - Humans
MH  - Interleukin 1 Receptor Antagonist Protein
MH  - Interleukin-1/biosynthesis
MH  - *Protein Biosynthesis
MH  - Proteins/genetics
MH  - RNA, Messenger/biosynthesis
MH  - Recombinant Proteins/biosynthesis
MH  - *Sialoglycoproteins
MH  - Transforming Growth Factor beta/*pharmacology
EDAT- 1991/07/01 00:00
MHDA- 1991/07/01 00:01
CRDT- 1991/07/01 00:00
PHST- 1991/07/01 00:00 [pubmed]
PHST- 1991/07/01 00:01 [medline]
PHST- 1991/07/01 00:00 [entrez]
AID - 10.1002/eji.1830210708 [doi]
PST - ppublish
SO  - Eur J Immunol. 1991 Jul;21(7):1635-9. doi: 10.1002/eji.1830210708.