PMID- 18294235
OWN - NLM
STAT- MEDLINE
DCOM- 20090917
LR  - 20090703
IS  - 1751-553X (Electronic)
IS  - 1751-5521 (Linking)
VI  - 31
IP  - 4
DP  - 2009 Aug
TI  - Translocations t(X;14)(q28;q11) and t(Y;14)(q12;q11) in T-cell prolymphocytic 
      leukemia.
PG  - 453-6
LID - 10.1111/j.1751-553X.2008.01036.x [doi]
AB  - We report a case of T-cell prolymphocytic leukemia (T-PLL) in a 41-year-old male. 
      Classical cytogenetic, spectral karyotyping (SKY) and fluorescence in situ 
      hybridization (FISH) studies of a blood sample obtained at diagnosis revealed the 
      co-existence of t(X;14)(q28;q11), t(Y;14)(q12;q11) and a ring chromosome derived 
      from i(8)(q10). Immunophenotypic studies revealed involvement of T-cell lineage, 
      with proliferation of CD4(-) CD8+. The co-existence of two translocations 
      involving both sex chromosomes in a case of T-PLL is rare. Chromosomal 
      instability associated with the disease progression may have allowed the 
      emergence of cell clones with translocations involving the sex chromosomes and 
      the ring chromosome observed.
FAU - de Oliveira, F M
AU  - de Oliveira FM
AD  - Department of Internal Medicine, School of Medicine of Ribeirao Preto, University 
      of Sao Paulo, Ribeirao Preto, SP, Brazil. morato.oliveira@yahoo.com.br
FAU - Tone, L G
AU  - Tone LG
FAU - Simoes, B P
AU  - Simoes BP
FAU - Rego, E M
AU  - Rego EM
FAU - Marinato, A F
AU  - Marinato AF
FAU - Jacomo, R H
AU  - Jacomo RH
FAU - Falcao, R P
AU  - Falcao RP
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20080214
PL  - England
TA  - Int J Lab Hematol
JT  - International journal of laboratory hematology
JID - 101300213
SB  - IM
MH  - Adult
MH  - Chromosomal Instability/genetics
MH  - Chromosomes, Human, Pair 14/*genetics
MH  - Chromosomes, Human, X/*genetics
MH  - Chromosomes, Human, Y/*genetics
MH  - Humans
MH  - Leukemia, Prolymphocytic, T-Cell/*genetics
MH  - Male
MH  - *Ring Chromosomes
MH  - Spectral Karyotyping
MH  - *Translocation, Genetic
EDAT- 2008/02/26 09:00
MHDA- 2009/09/18 06:00
CRDT- 2008/02/26 09:00
PHST- 2008/02/26 09:00 [pubmed]
PHST- 2009/09/18 06:00 [medline]
PHST- 2008/02/26 09:00 [entrez]
AID - CLH1036 [pii]
AID - 10.1111/j.1751-553X.2008.01036.x [doi]
PST - ppublish
SO  - Int J Lab Hematol. 2009 Aug;31(4):453-6. doi: 10.1111/j.1751-553X.2008.01036.x. 
      Epub 2008 Feb 14.