PMID- 18294761
OWN - NLM
STAT- MEDLINE
DCOM- 20140911
LR  - 20091209
IS  - 1873-7560 (Electronic)
IS  - 0302-2838 (Linking)
VI  - 55
IP  - 1
DP  - 2009 Jan
TI  - Two modes of acupuncture as a treatment for hot flushes in men with prostate 
      cancer--a prospective multicenter study with long-term follow-up.
PG  - 156-63
LID - 10.1016/j.eururo.2008.02.002 [doi]
AB  - BACKGROUND: Hot flushes are common and distressing among men with castrational 
      treatment for prostate cancer. Of the few treatments, most have side effects. 
      OBJECTIVE: Assess changes in hot flushes of electrostimulated (EA) and 
      traditional acupuncture (TA). DESIGN, SETTING, AND PARTICIPANTS: Thirty-one men 
      with hot flushes due to prostate cancer treatment were recruited from three 
      urological departments in Sweden, from 2001 to 2004. INTERVENTION: Thirty-one men 
      were randomized to EA (12 needle points, with 4 electrostimulated) or TA (12 
      needle points) weekly for 12 wk. PRIMARY OUTCOME: number of and distress from hot 
      flushes in 24 h and change in "hot flush score." Secondary outcome: change in 
      24-h urine excretion of CGRP (calcitonin gene-related peptide). RESULTS AND 
      LIMITATIONS: Twenty-nine men completed the treatment. Hot flushes per 24 h 
      decreased significantly, from a median of 7.6 (interquartile range [IQR], 
      6.0-12.3) at baseline in the EA group to 4.1 (IQR, 2.0-6.5) (p=0.012) after 12 
      wk, and from 5.7 (IQR, 5.1-9.5) in the TA group to 3.4 (IQR1.8-6.3) (p=0.001). 
      Distress by flushes decreased from 8.2 (IQR, 6.5-10.7) in the EA group to 3.3 
      (IQR, 0.3-8.1) (p=0.003), and from 7.6 (IQR, 4.7-8.3) to 3.4 (IQR, 2.0-5.6) 
      (p=0.001) in the TA group after 12 wk, (78% and 73% reduction in "hot flush 
      score," respectively). The effect lasted up to 9 mo after treatment ended. CGRP 
      did not change significantly. Few, minor side effects were reported. LIMITATIONS: 
      small number of patients; no placebo control, instead a small group controlled 
      for 6 wk pretreatment. CONCLUSIONS: EA and TA lowered number of and distress from 
      hot flushes. The hot flush score decreased 78% and 73%, respectively, in line 
      with or better than medical regimens for these symptoms. Acupuncture should be 
      considered an alternative treatment for these symptoms, but further evaluation is 
      needed, preferably with a non- or placebo-treated control group.
FAU - Frisk, Jessica
AU  - Frisk J
AD  - Division of Obstetrics and Gynaecology, Department of Clinical and Experimental 
      Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden. 
      jessica.frisk@imk.liu.se
FAU - Spetz, Anna-Clara
AU  - Spetz AC
FAU - Hjertberg, Hans
AU  - Hjertberg H
FAU - Petersson, Bill
AU  - Petersson B
FAU - Hammar, Mats
AU  - Hammar M
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20080214
PL  - Switzerland
TA  - Eur Urol
JT  - European urology
JID - 7512719
SB  - IM
MH  - Acupuncture Therapy/*methods
MH  - Aged
MH  - Double-Blind Method
MH  - Electroacupuncture
MH  - Follow-Up Studies
MH  - Hot Flashes/etiology/*therapy
MH  - Humans
MH  - Male
MH  - Prospective Studies
MH  - Prostatic Neoplasms/complications/therapy
MH  - Time Factors
EDAT- 2008/02/26 09:00
MHDA- 2014/09/12 06:00
CRDT- 2008/02/26 09:00
PHST- 2007/11/01 00:00 [received]
PHST- 2008/02/06 00:00 [accepted]
PHST- 2008/02/26 09:00 [pubmed]
PHST- 2014/09/12 06:00 [medline]
PHST- 2008/02/26 09:00 [entrez]
AID - S0302-2838(08)00169-3 [pii]
AID - 10.1016/j.eururo.2008.02.002 [doi]
PST - ppublish
SO  - Eur Urol. 2009 Jan;55(1):156-63. doi: 10.1016/j.eururo.2008.02.002. Epub 2008 Feb 
      14.