PMID- 18295340
OWN - NLM
STAT- MEDLINE
DCOM- 20080911
LR  - 20211020
IS  - 0165-0173 (Print)
IS  - 0165-0173 (Linking)
VI  - 58
IP  - 1
DP  - 2008 Jun
TI  - Interleukin-18 and stress.
PG  - 85-95
LID - 10.1016/j.brainresrev.2007.11.003 [doi]
AB  - Interleukin-18 (IL-18) is a pro-inflammatory cytokine believed to play a role in 
      a variety of conditions and diseases including infections, autoimmunity, cancer, 
      diabetes and atherosclerosis. IL-18 is also a possible contributor to the 
      sickness syndrome by inducing anorexia and sleep. Originally recognized to be 
      produced by cells of the immune system, IL-18 is also found in endocrine tissues, 
      including the adrenal and the pituitary glands, and in the central nervous system 
      where it is produced by microglial and ependymal cells as well as by neurons of 
      the medial habenular nucleus. IL-18 is produced constitutively and its levels can 
      increase during infection but also during stress in the absence of an exogenous 
      stimulus. IL-18 levels are elevated by activation of the 
      hypothalamic-pituitary-adrenal (HPA) axis in a tissue specific way via 
      differential promoter and splicing usage, and may be down-regulated by the 
      activation of the para-sympathetic system. This suggested the possibility that 
      IL-18 may participate in the regulation of the HPA axis or that it may have a 
      role in mediating the CNS dependent effects on the susceptibility to or the 
      progression of diseases. This review summarizes the evidence linking stress and 
      IL-18 and discusses the possible implication of the neuro-immuno-modulatory 
      action of IL-18.
FAU - Sugama, Shuei
AU  - Sugama S
AD  - Department of Physiology, Nippon Medical School, 1-1-5 Sendagi Bunkyo-ku, Tokyo 
      113-8602, Japan. sugama@nms.ec.jp
FAU - Conti, Bruno
AU  - Conti B
LA  - eng
GR  - R01 AG028040/AG/NIA NIH HHS/United States
GR  - AG028040/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20071128
PL  - Netherlands
TA  - Brain Res Rev
JT  - Brain research reviews
JID - 101300366
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Hypothalamo-Hypophyseal System/physiology
MH  - Interleukin-18/biosynthesis/*genetics/*physiology
MH  - Parasympathetic Nervous System/physiology
MH  - Pituitary-Adrenal System/physiology
MH  - Promoter Regions, Genetic/genetics
MH  - RNA Splicing
MH  - Stress, Physiological/metabolism/*physiopathology
RF  - 126
EDAT- 2008/02/26 09:00
MHDA- 2008/09/13 09:00
CRDT- 2008/02/26 09:00
PHST- 2007/08/01 00:00 [received]
PHST- 2007/11/02 00:00 [revised]
PHST- 2007/11/16 00:00 [accepted]
PHST- 2008/02/26 09:00 [pubmed]
PHST- 2008/09/13 09:00 [medline]
PHST- 2008/02/26 09:00 [entrez]
AID - S0165-0173(07)00265-2 [pii]
AID - 10.1016/j.brainresrev.2007.11.003 [doi]
PST - ppublish
SO  - Brain Res Rev. 2008 Jun;58(1):85-95. doi: 10.1016/j.brainresrev.2007.11.003. Epub 
      2007 Nov 28.