PMID- 18295772
OWN - NLM
STAT- MEDLINE
DCOM- 20080626
LR  - 20151119
IS  - 0021-9673 (Print)
IS  - 0021-9673 (Linking)
VI  - 1187
IP  - 1-2
DP  - 2008 Apr 11
TI  - Determination of antibiotics in aquatic environment by solid-phase extraction 
      followed by liquid chromatography-electrospray ionization mass spectrometry.
PG  - 151-64
LID - 10.1016/j.chroma.2008.02.021 [doi]
AB  - A robust and sensitive solid-phase extraction followed by liquid 
      chromatography-electrospray ionization mass spectrometric (LC-ESI-MS) method for 
      determination of antibiotics viz., fluoroquinolones, sulfamethoxazole, 
      trimethoprim and cephalosporines in surface waters was developed. The sample 
      recoveries on Oasis HLB cartridges were found to be >80%. Identification was 
      carried out by LC-ESI-MS/MS. The positive ion ESI mass spectra containing the 
      peaks of quasimolecular ions [M+H](+) allowed the determination of molecular 
      masses whereas the fragment ions obtained by MS/MS of [M+H](+) ions permitted the 
      structural assignment. Quantification was carried out by selective ion monitoring 
      (SIM) using the quasimolecular ions [M+H](+) of the parent compounds. The 
      detection and quantification limits were found to be in the range of 0.6-8.1 and 
      2.0-24.0 microg/L. The surface waters of different lakes and tanks of Hyderabad, 
      India were found to contain a few antibiotics.
FAU - Nageswara Rao, R
AU  - Nageswara Rao R
AD  - Analytical Chemistry Division, Discovery Laboratory, Indian Institute of Chemical 
      Technology, Tarnaka, Hyderabad 500007, India. rnrao55@yahoo.com
FAU - Venkateswarlu, N
AU  - Venkateswarlu N
FAU - Narsimha, R
AU  - Narsimha R
LA  - eng
PT  - Journal Article
DEP - 20080212
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Cephalosporins)
RN  - 0 (Fluoroquinolones)
RN  - 0 (Water Pollutants, Chemical)
RN  - 8064-90-2 (Trimethoprim, Sulfamethoxazole Drug Combination)
SB  - IM
MH  - Anti-Bacterial Agents/*analysis
MH  - Cephalosporins/analysis
MH  - Chromatography, Liquid/*methods
MH  - Fluoroquinolones/analysis
MH  - Hydrogen-Ion Concentration
MH  - Solid Phase Extraction/*methods
MH  - Spectrometry, Mass, Electrospray Ionization/*methods
MH  - Trimethoprim, Sulfamethoxazole Drug Combination/analysis
MH  - Water Pollutants, Chemical/*analysis
EDAT- 2008/02/26 09:00
MHDA- 2008/06/27 09:00
CRDT- 2008/02/26 09:00
PHST- 2007/06/18 00:00 [received]
PHST- 2008/02/05 00:00 [revised]
PHST- 2008/02/07 00:00 [accepted]
PHST- 2008/02/26 09:00 [pubmed]
PHST- 2008/06/27 09:00 [medline]
PHST- 2008/02/26 09:00 [entrez]
AID - S0021-9673(08)00264-1 [pii]
AID - 10.1016/j.chroma.2008.02.021 [doi]
PST - ppublish
SO  - J Chromatogr A. 2008 Apr 11;1187(1-2):151-64. doi: 10.1016/j.chroma.2008.02.021. 
      Epub 2008 Feb 12.