PMID- 18298660
OWN - NLM
STAT- MEDLINE
DCOM- 20081113
LR  - 20211027
IS  - 1582-1838 (Print)
IS  - 1582-4934 (Electronic)
IS  - 1582-1838 (Linking)
VI  - 12
IP  - 4
DP  - 2008 Aug
TI  - Gene expression profiling demonstrates a novel role for foetal fibrocytes and the 
      umbilical vessels in human fetoplacental development.
PG  - 1317-30
LID - 10.1111/j.1582-4934.2008.00284.x [doi]
AB  - There is a difference in the susceptibility to inflammation between the umbilical 
      vein (UV) and the umbilical arteries (UAs). This led us to hypothesize that there 
      is an intrinsic difference in the pro-inflammatory response between UA and UV. 
      Real-time quantitative RT-PCR and microarray analysis revealed higher expression 
      of interleukin (IL)-1beta and IL-8 mRNA in the UV and differential expression of 
      567 genes between the UA and UV associated with distinct biological processes, 
      including the immune response. Differential expression of human leukocyte antigen 
      (HLA)-DRA mRNA between the UA and UV was due to unexpected HLA-DR(+) cells 
      migrating via the umbilical vessels into Wharton's jelly, more frequently in the 
      UV. A significant proportion of these cells co-expressed CD45 and type I 
      pro-collagen, and acquired CD163 or alpha-smooth muscle actin immunoreactivity in 
      Wharton's jelly. Migrating cells were also found in the chorionic and stem 
      villous vessels. Furthermore, the extent of migration increased with progression 
      of gestation, but diminished in intrauterine growth restriction (IUGR). The 
      observations herein strongly suggest that circulating foetal fibrocytes, routing 
      via umbilical and placental vessels, are a reservoir for key cellular subsets in 
      the placenta. This study reports fibrocytes in the human umbilical cord and 
      placenta for the first time, and a novel role for both circulating foetal cells 
      and the umbilical vessels in placental development, which is deranged in IUGR.
FAU - Kim, Jung-Sun
AU  - Kim JS
AD  - Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD, USA.
FAU - Romero, Roberto
AU  - Romero R
FAU - Tarca, Adi Laurentiu
AU  - Tarca AL
FAU - LaJeunesse, Christopher
AU  - LaJeunesse C
FAU - Han, Yu Mi
AU  - Han YM
FAU - Kim, Mi Jeong
AU  - Kim MJ
FAU - Suh, Yeon Lim
AU  - Suh YL
FAU - Draghici, Sorin
AU  - Draghici S
FAU - Mittal, Pooja
AU  - Mittal P
FAU - Gotsch, Francesca
AU  - Gotsch F
FAU - Kusanovic, Juan Pedro
AU  - Kusanovic JP
FAU - Hassan, Sonia
AU  - Hassan S
FAU - Kim, Chong Jai
AU  - Kim CJ
LA  - eng
GR  - Z01 HD002400-17/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20080224
PL  - England
TA  - J Cell Mol Med
JT  - Journal of cellular and molecular medicine
JID - 101083777
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-8)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Cell Count
MH  - Embryonic Development/*genetics
MH  - Female
MH  - Fetus/*cytology/metabolism
MH  - Fibroblasts/cytology
MH  - *Gene Expression Profiling
MH  - Gene Expression Regulation
MH  - HLA-DR Antigens/immunology
MH  - Humans
MH  - Immunophenotyping
MH  - Interleukin-1beta/genetics/metabolism
MH  - Interleukin-8/genetics/metabolism
MH  - Macrophages/cytology
MH  - Microarray Analysis
MH  - Models, Biological
MH  - Placenta/*embryology/metabolism
MH  - Pregnancy
MH  - RNA, Messenger/genetics/metabolism
MH  - Software
MH  - Umbilical Arteries/cytology/immunology/*metabolism
MH  - Umbilical Veins/cytology/immunology/*metabolism
PMC - PMC2837362
MID - NIHMS160440
EDAT- 2008/02/27 09:00
MHDA- 2008/11/14 09:00
PMCR- 2008/08/01
CRDT- 2008/02/27 09:00
PHST- 2008/02/27 09:00 [pubmed]
PHST- 2008/11/14 09:00 [medline]
PHST- 2008/02/27 09:00 [entrez]
PHST- 2008/08/01 00:00 [pmc-release]
AID - JCMM284 [pii]
AID - 10.1111/j.1582-4934.2008.00284.x [doi]
PST - ppublish
SO  - J Cell Mol Med. 2008 Aug;12(4):1317-30. doi: 10.1111/j.1582-4934.2008.00284.x. 
      Epub 2008 Feb 24.