PMID- 18298797
OWN - NLM
STAT- MEDLINE
DCOM- 20080915
LR  - 20171116
IS  - 1365-2443 (Electronic)
IS  - 1356-9597 (Linking)
VI  - 13
IP  - 3
DP  - 2008 Mar
TI  - Cop9 signalosome subunit 8 (CSN8) is essential for Drosophila development.
PG  - 221-31
LID - 10.1111/j.1365-2443.2008.01164.x [doi]
AB  - The COP9 signalosome (CSN) is a multisubunit regulator highly conserved in 
      evolution. We show here that CSN subunit 8 (CSN8) is essential for Drosophila 
      development. CSN8 is maternally contributed and present throughout development. 
      Null mutants generated in this study are larval lethal, showing phenotypes 
      associated with mutations in either CSN4 (molting defects) or CSN5 (melanotic 
      tumors). Analysis of mitotic and germ-line csn8(null) clones revealed the 
      requirement of CSN8 for multiple developmental processes. The germ-line clones 
      arrested at mid-oogenesis, while the mitotic clones led to deformed adult eyes or 
      wings. CSN8 is present exclusively as part of the CSN holo-complex, and lack of 
      CSN8 in the mutants leads to CSN instability. Consistent with this, Cullin 
      deneddylation is impaired in the csn8(null) mutants.
FAU - Oren-Giladi, Pazit
AU  - Oren-Giladi P
AD  - Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel 
      Aviv, Israel.
FAU - Krieger, Ofra
AU  - Krieger O
FAU - Edgar, Bruce A
AU  - Edgar BA
FAU - Chamovitz, Daniel A
AU  - Chamovitz DA
FAU - Segal, Daniel
AU  - Segal D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Genes Cells
JT  - Genes to cells : devoted to molecular & cellular mechanisms
JID - 9607379
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (CSN4 protein, Drosophila)
RN  - 0 (CSN8 protein, Drosophila)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Multiprotein Complexes)
RN  - 0 (Nuclear Proteins)
RN  - 0 (RNA, Messenger)
RN  - EC 3.4.- (Peptide Hydrolases)
RN  - EC 3.4.-.- (CSN5 protein, Drosophila)
RN  - EC 3.4.19.12 (COP9 Signalosome Complex)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Animals
MH  - Animals, Genetically Modified
MH  - COP9 Signalosome Complex
MH  - Drosophila/*genetics/*growth & development
MH  - Drosophila Proteins/*genetics/metabolism
MH  - Gene Targeting
MH  - Genes, Lethal
MH  - Intracellular Signaling Peptides and Proteins/genetics
MH  - Larva/genetics/growth & development
MH  - Life Cycle Stages/genetics
MH  - Meiosis
MH  - Melanoma/*genetics
MH  - Multiprotein Complexes/*genetics
MH  - Mutation
MH  - Nuclear Proteins/*genetics/metabolism
MH  - Oogenesis/genetics
MH  - Peptide Hydrolases/*genetics
MH  - Phenotype
MH  - RNA, Messenger/genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2008/02/27 09:00
MHDA- 2008/09/16 09:00
CRDT- 2008/02/27 09:00
PHST- 2008/02/27 09:00 [pubmed]
PHST- 2008/09/16 09:00 [medline]
PHST- 2008/02/27 09:00 [entrez]
AID - GTC1164 [pii]
AID - 10.1111/j.1365-2443.2008.01164.x [doi]
PST - ppublish
SO  - Genes Cells. 2008 Mar;13(3):221-31. doi: 10.1111/j.1365-2443.2008.01164.x.