PMID- 18299120
OWN - NLM
STAT- MEDLINE
DCOM- 20080728
LR  - 20080324
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1201
DP  - 2008 Mar 27
TI  - Comparative study of the effects of electrical stimulation in the nucleus 
      accumbens, the mediodorsal thalamic nucleus and the bed nucleus of the stria 
      terminalis in rats with schedule-induced polydipsia.
PG  - 93-9
LID - 10.1016/j.brainres.2008.01.043 [doi]
AB  - In the schedule-induced polydipsia model, hungry rats receiving a food pellet 
      every minute will display excessive drinking behaviour (compulsive behaviour). We 
      aimed 1) to evaluate if electrical stimulation in the nucleus accumbens (N ACC), 
      the mediodorsal thalamic nucleus (MD) or the bed nucleus of the stria terminalis 
      (BST) can decrease water intake in the schedule-induced polydipsia model; 2) to 
      compare water intake between these groups for different stimulation amplitudes; 
      and 3) to compare the effect of low frequency (2 Hz) with high frequency (100 Hz) 
      stimulation. Rats were randomly divided into four groups: electrode implanted in 
      the 1) N ACC (n=7), 2) MD (n=8), 3) BST (n=8), or 4) a sham-operated control 
      group (n=7). Postoperatively, each rat of group 1, 2 and 3 was randomly tested in 
      the model using pulses with a frequency of 2 Hz and 100 Hz, each at an amplitude 
      of 0.1, 0.2, 0.3, 0.4 and 0.5 mA, or without stimulation. Group 4 was tested 11 
      times without stimulation. Each day the rats were tested in random order. 
      High-frequency electrical stimulation in all three brain areas decreased water 
      intake significantly at an amplitude of 0.2 mA or higher, however, without 
      differences between the brain areas. Based on these results, we expect a decrease 
      in compulsions in patients suffering from treatment-resistant 
      obsessive-compulsive disorder during electrical stimulation in the N ACC, the MD 
      and the BST. However, we foresee no difference in energy consumption to decrease 
      symptoms during electrical stimulation between these brain areas.
FAU - van Kuyck, Kris
AU  - van Kuyck K
AD  - Laboratory of Experimental Functional Neurosurgery, Department of Neurosciences, 
      K.U.Leuven, Provisorium I, Minderbroedersstraat 17, 3000 Leuven, Belgium.
FAU - Brak, Katrien
AU  - Brak K
FAU - Das, John
AU  - Das J
FAU - Rizopoulos, Dimitris
AU  - Rizopoulos D
FAU - Nuttin, Bart
AU  - Nuttin B
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080126
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
SB  - IM
MH  - Animals
MH  - Drinking/*physiology
MH  - Electric Stimulation/methods
MH  - Electric Stimulation Therapy
MH  - Energy Metabolism/physiology
MH  - Male
MH  - Mediodorsal Thalamic Nucleus/anatomy & histology/*physiology
MH  - Neural Pathways/physiology
MH  - Nucleus Accumbens/anatomy & histology/*physiology
MH  - Obsessive-Compulsive Disorder/physiopathology/therapy
MH  - Rats
MH  - Rats, Wistar
MH  - Septal Nuclei/anatomy & histology/*physiology
MH  - Thirst/*physiology
EDAT- 2008/02/27 09:00
MHDA- 2008/07/29 09:00
CRDT- 2008/02/27 09:00
PHST- 2007/05/07 00:00 [received]
PHST- 2007/12/12 00:00 [revised]
PHST- 2008/01/15 00:00 [accepted]
PHST- 2008/02/27 09:00 [pubmed]
PHST- 2008/07/29 09:00 [medline]
PHST- 2008/02/27 09:00 [entrez]
AID - S0006-8993(08)00147-9 [pii]
AID - 10.1016/j.brainres.2008.01.043 [doi]
PST - ppublish
SO  - Brain Res. 2008 Mar 27;1201:93-9. doi: 10.1016/j.brainres.2008.01.043. Epub 2008 
      Jan 26.