PMID- 18299450
OWN - NLM
STAT- MEDLINE
DCOM- 20080716
LR  - 20211020
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 111
IP  - 9
DP  - 2008 May 1
TI  - DDX3Y encodes a class I MHC-restricted H-Y antigen that is expressed in leukemic 
      stem cells.
PG  - 4817-26
LID - 10.1182/blood-2007-06-096313 [doi]
AB  - The Y chromosome encodes male-specific minor histocompatibility (H-Y) antigens 
      that stimulate T- and B-lymphocyte responses after sex-mismatched allogeneic 
      hematopoietic cell transplantation (HCT). A CD8(+) cytotoxic T lymphocyte (CTL) 
      clone that recognizes a novel HLA-B*2705-restricted H-Y antigen encoded by the 
      DDX3Y gene was isolated from a male who had received a hematopoietic cell graft 
      from his human leukocyte antigen (HLA)-identical sister. The antigenic peptide is 
      a decamer that differs from the homologous DDX3X-encoded peptide at 4 positions. 
      Expression of DDX3Y and of the H-Y epitope that it encodes was examined by 
      quantitative polymerase chain reaction (PCR) and by CTL recognition assays. 
      Expression of DDX3Y is detected in all myeloid and lymphoid leukemic cells that 
      carry an intact Y chromosome. Moreover, the DDX3Y-encoded H-Y epitope is 
      presented on the surface of both myeloid and lymphoid leukemic cells from male 
      HLA-B*2705(+) patients. DDX3Y-specific CTLs prevent engraftment of human acute 
      leukemia in nonobese diabetic/severe combined immune deficient mice, 
      demonstrating that the DDX3Y-encoded H-Y antigen is also expressed in leukemic 
      stem cells. These results demonstrate that CD8(+) T-cell responses against DDX3Y 
      have the potential to contribute to graft-versus-leukemia (GVL) activity after 
      female into male allogeneic HCT. This study is registered at 
      http://clinicaltrials.gov as NCT00107354.
FAU - Rosinski, Kellie V
AU  - Rosinski KV
AD  - Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 
      98109-1024, USA.
FAU - Fujii, Nobuharu
AU  - Fujii N
FAU - Mito, Jeffrey K
AU  - Mito JK
FAU - Koo, Kevin K W
AU  - Koo KK
FAU - Xuereb, Suzanne M
AU  - Xuereb SM
FAU - Sala-Torra, Olga
AU  - Sala-Torra O
FAU - Gibbs, James S
AU  - Gibbs JS
FAU - Radich, Jerald P
AU  - Radich JP
FAU - Akatsuka, Yoshiki
AU  - Akatsuka Y
FAU - Van den Eynde, Benoit J
AU  - Van den Eynde BJ
FAU - Riddell, Stanley R
AU  - Riddell SR
FAU - Warren, Edus H
AU  - Warren EH
LA  - eng
SI  - ClinicalTrials.gov/NCT00107354
GR  - CA18029/CA/NCI NIH HHS/United States
GR  - P01 CA018029/CA/NCI NIH HHS/United States
GR  - P30 DK056465/DK/NIDDK NIH HHS/United States
GR  - DK56465/DK/NIDDK NIH HHS/United States
GR  - R01 CA106512/CA/NCI NIH HHS/United States
GR  - CA106512/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080225
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (H-Y Antigen)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Minor Histocompatibility Antigens)
RN  - EC 3.6.1.- (DDX3Y protein, human)
RN  - EC 3.6.4.13 (DEAD-box RNA Helicases)
SB  - IM
MH  - Animals
MH  - CD8-Positive T-Lymphocytes
MH  - DEAD-box RNA Helicases/analysis/*immunology
MH  - Female
MH  - Graft vs Leukemia Effect
MH  - *H-Y Antigen/analysis
MH  - Hematopoietic Stem Cell Transplantation
MH  - *Histocompatibility Antigens Class I
MH  - Humans
MH  - Leukemia/*pathology
MH  - Male
MH  - Mice
MH  - Mice, SCID
MH  - Minor Histocompatibility Antigens
MH  - Neoplastic Stem Cells/*immunology
MH  - T-Lymphocytes, Cytotoxic
MH  - Transplantation, Heterologous
PMC - PMC2343610
EDAT- 2008/02/27 09:00
MHDA- 2008/07/17 09:00
PMCR- 2009/05/01
CRDT- 2008/02/27 09:00
PHST- 2008/02/27 09:00 [pubmed]
PHST- 2008/07/17 09:00 [medline]
PHST- 2008/02/27 09:00 [entrez]
PHST- 2009/05/01 00:00 [pmc-release]
AID - S0006-4971(20)41174-7 [pii]
AID - 2007/096313 [pii]
AID - 10.1182/blood-2007-06-096313 [doi]
PST - ppublish
SO  - Blood. 2008 May 1;111(9):4817-26. doi: 10.1182/blood-2007-06-096313. Epub 2008 
      Feb 25.