PMID- 18300699
OWN - NLM
STAT- MEDLINE
DCOM- 20080602
LR  - 20211020
IS  - 1525-4135 (Print)
IS  - 1525-4135 (Linking)
VI  - 48
IP  - 1
DP  - 2008 May 1
TI  - Plasmacytoid and myeloid dendritic cells with a partial activation phenotype 
      accumulate in lymphoid tissue during asymptomatic chronic HIV-1 infection.
PG  - 1-12
LID - 10.1097/QAI.0b013e3181664b60 [doi]
AB  - Dendritic cells (DCs) from HIV-1-infected individuals display numeric and 
      functional defects, and recent evidence suggests that HIV-1 can directly and 
      indirectly activate DCs in vitro. The in vivo activation state and 
      compartmentalization of DC subsets during HIV-1 infection remain poorly 
      understood, however. We evaluated phenotypic and functional characteristics of 
      myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs) directly 
      ex vivo in peripheral blood and lymphoid tissue from HIV-1-infected and 
      HIV-seronegative individuals. Analysis of a wide range of chemokine receptors and 
      activation/maturation markers on circulating DCs from viremic HIV-1-infected 
      donors revealed a phenotype indicative of partial activation. Yet, blood DCs from 
      viremic subjects still achieved full maturation when stimulated in vitro. In 
      addition, blood pDCs from viremic individuals had a reduced capacity to migrate 
      to CXCL12 in vitro. Total numbers of both DC subsets were increased in lymph 
      nodes of asymptomatic untreated HIV-1-infected subjects, consistent with DC 
      accumulation in the lymphoid compartment. Lymph node DCs also expressed high 
      levels of CD40 in the absence of increases of other typical activation/maturation 
      markers. Activation and depletion of DCs in blood with accumulation in lymphoid 
      tissue may contribute to HIV-associated chronic immune activation and T-cell 
      dysfunction.
FAU - Dillon, Stephanie M
AU  - Dillon SM
AD  - Division of Infectious Diseases, Department of Medicine, University of Colorado 
      Health Sciences Center, Denver, CO 80262, USA.
FAU - Robertson, Kathryn B
AU  - Robertson KB
FAU - Pan, Samuel C
AU  - Pan SC
FAU - Mawhinney, Samantha
AU  - Mawhinney S
FAU - Meditz, Amie L
AU  - Meditz AL
FAU - Folkvord, Joy M
AU  - Folkvord JM
FAU - Connick, Elizabeth
AU  - Connick E
FAU - McCarter, Martin D
AU  - McCarter MD
FAU - Wilson, Cara C
AU  - Wilson CC
LA  - eng
GR  - P01 AI055356-010002/AI/NIAID NIH HHS/United States
GR  - R01 AI065275-02/AI/NIAID NIH HHS/United States
GR  - R21 HD 051450/HD/NICHD NIH HHS/United States
GR  - P01 AI 55356/AI/NIAID NIH HHS/United States
GR  - R21 HD051450/HD/NICHD NIH HHS/United States
GR  - P30 AI054907/AI/NIAID NIH HHS/United States
GR  - R21 HD051450-02/HD/NICHD NIH HHS/United States
GR  - R01 AI065275/AI/NIAID NIH HHS/United States
GR  - R01 AI 065275/AI/NIAID NIH HHS/United States
GR  - R01 AI065275-01A2/AI/NIAID NIH HHS/United States
GR  - R21 HD051450-01A2/HD/NICHD NIH HHS/United States
GR  - R01 AI065275-03/AI/NIAID NIH HHS/United States
GR  - AI 054907/AI/NIAID NIH HHS/United States
GR  - P01 AI055356/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
RN  - 0 (DNA Primers)
SB  - IM
MH  - Base Sequence
MH  - DNA Primers
MH  - Dendritic Cells/*immunology
MH  - Flow Cytometry
MH  - HIV Infections/immunology/*pathology
MH  - HIV-1
MH  - Humans
MH  - Lymphoid Tissue/immunology/*pathology
MH  - Phenotype
PMC - PMC2529020
MID - NIHMS64239
EDAT- 2008/02/28 09:00
MHDA- 2008/06/03 09:00
PMCR- 2008/09/04
CRDT- 2008/02/28 09:00
PHST- 2008/02/28 09:00 [pubmed]
PHST- 2008/06/03 09:00 [medline]
PHST- 2008/02/28 09:00 [entrez]
PHST- 2008/09/04 00:00 [pmc-release]
AID - 10.1097/QAI.0b013e3181664b60 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2008 May 1;48(1):1-12. doi: 
      10.1097/QAI.0b013e3181664b60.