PMID- 18301423
OWN - NLM
STAT- MEDLINE
DCOM- 20080324
LR  - 20081121
IS  - 1474-1741 (Electronic)
IS  - 1474-1733 (Linking)
VI  - 8
IP  - 3
DP  - 2008 Mar
TI  - Dendritic cells and epithelial cells: linking innate and adaptive immunity in 
      asthma.
PG  - 193-204
LID - 10.1038/nri2275 [doi]
AB  - Dendritic cells (DCs) are generally held responsible for initiating and 
      maintaining allergic T helper 2 (T(H)2)-cell responses to inhaled allergens in 
      asthma. Although the epithelium was initially considered to function solely as a 
      physical barrier, it is now seen as a central player in the T(H)2-cell 
      sensitization process by influencing the function of DCs. Clinically relevant 
      allergens, as well as known environmental and genetic risk factors for allergy 
      and asthma, often interfere directly or indirectly with the innate immune 
      functions of airway epithelial cells and DCs. A better understanding of these 
      interactions, ascertained from human and animal studies, might lead to better 
      prevention and treatment of asthma.
FAU - Hammad, Hamida
AU  - Hammad H
AD  - Department of Respiratory Diseases, Laboratory of Immunoregulation and Mucosal 
      Immunology, University Hospital Ghent, Belgium.
FAU - Lambrecht, Bart N
AU  - Lambrecht BN
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - England
TA  - Nat Rev Immunol
JT  - Nature reviews. Immunology
JID - 101124169
SB  - IM
MH  - Animals
MH  - Asthma/*immunology/pathology
MH  - Dendritic Cells/*immunology/pathology
MH  - Epithelial Cells/*immunology/pathology
MH  - Humans
MH  - Immunity, Innate/*immunology
RF  - 131
EDAT- 2008/02/28 09:00
MHDA- 2008/03/25 09:00
CRDT- 2008/02/28 09:00
PHST- 2008/02/28 09:00 [pubmed]
PHST- 2008/03/25 09:00 [medline]
PHST- 2008/02/28 09:00 [entrez]
AID - nri2275 [pii]
AID - 10.1038/nri2275 [doi]
PST - ppublish
SO  - Nat Rev Immunol. 2008 Mar;8(3):193-204. doi: 10.1038/nri2275.