PMID- 18301844
OWN - NLM
STAT- MEDLINE
DCOM- 20080317
LR  - 20151119
IS  - 2737-5935 (Electronic)
IS  - 0037-5675 (Linking)
VI  - 49
IP  - 2
DP  - 2008 Feb
TI  - Inpatient paediatric use of intravenous immunoglobulin at an academic medical 
      centre.
PG  - 147-9
AB  - INTRODUCTION: Intravenous immunoglobulin (IVIG) is an important research topic 
      because of its efficacy in the management of an increasing number of diseases, 
      its high cost and limited availability. This study was designed to evaluate the 
      paediatric inpatient use of IVIG and identify strategies to reduce the drug 
      expenditures. METHODS: Over a six-month period, physician and nursing charts, and 
      notes for subjects who were treated with IVIG, were reviewed to gather the 
      required data. This included patient demographics, IVIG, indications, dosage 
      regimen, adverse drug reactions (ADRs) and their management. RESULTS: 58.3 
      percent of IVIG infusions were ordered for labelled indications. Patients in the 
      labelled group experienced more clinical improvement than subjects in the 
      off-label group. Haematologists and neurologists were the most prevalent 
      prescribers. ADRs were more prevalent in the off-label group. Hypotension, fever, 
      headache and chills were the most common adverse effects. ADRs were managed with 
      drugs in 22.9 percent of IVIG administrations and IVIG infusions were modified in 
      12.5 percent of infusions. CONCLUSION: ADRs were more prevalent in this hospital 
      than those reported by other authors. This may be due to nursing negligence of 
      the recommended infusion rate, higher sensitivity of our population or to the 
      brands of IVIG which are used in the hospital. This shows the need for further 
      evaluation of IVIG prescription and administration.
FAU - Dashti-Khavidaki, S
AU  - Dashti-Khavidaki S
AD  - Department of Clinical Pharmacy (Pharmacotherapy), School of Pharmacy, Tehran 
      University of Medical Sciences, Poursina Ave, PO Box 14155/6451, Tehran 14174, 
      Iran.
FAU - Khalili, H
AU  - Khalili H
FAU - Farshadi, F
AU  - Farshadi F
FAU - Aghamohammadi, A
AU  - Aghamohammadi A
FAU - Movahedi, M
AU  - Movahedi M
FAU - Hajibabaei, M
AU  - Hajibabaei M
LA  - eng
PT  - Journal Article
PL  - India
TA  - Singapore Med J
JT  - Singapore medical journal
JID - 0404516
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Academic Medical Centers
MH  - Child
MH  - *Drug Utilization Review
MH  - Female
MH  - Hospitals, Pediatric
MH  - Humans
MH  - Immunoglobulins, Intravenous/*adverse effects/therapeutic use
MH  - Male
MH  - *Medical Audit
MH  - Practice Patterns, Physicians'/*statistics & numerical data
EDAT- 2008/02/28 09:00
MHDA- 2008/03/18 09:00
CRDT- 2008/02/28 09:00
PHST- 2008/02/28 09:00 [pubmed]
PHST- 2008/03/18 09:00 [medline]
PHST- 2008/02/28 09:00 [entrez]
PST - ppublish
SO  - Singapore Med J. 2008 Feb;49(2):147-9.