PMID- 18302842
OWN - NLM
STAT- MEDLINE
DCOM- 20080605
LR  - 20161020
IS  - 1088-5412 (Print)
IS  - 1088-5412 (Linking)
VI  - 29
IP  - 1
DP  - 2008 Jan-Feb
TI  - Immunoglobulin E levels in the 1st year of life.
PG  - 74-7
LID - 10.2500/aap2008.29.3081 [doi]
AB  - Asthma allergic rhinitis and atopic dermatitis are multifactorial disorders 
      influenced by various familial and environmental factors. The correlation between 
      maternal and fetal immunoglobulin E (IgE) seems to be caused by genetic factors 
      rather than placental transfer. The purpose of this study was to evaluate and 
      quantify the relationship of IgE levels between mothers and their offspring 
      during the 1st year of life. Total serum IgE levels were assessed in 104 healthy 
      pregnant women just before delivery, as well as in 104 newborns in the 1st days 
      of life and then again at 3, 5, 6, 11 and 12 months of age. A serum IgE increase 
      in infants during the 1st year of life is related to maternal serum IgE levels 
      (and may be divided into three classes, according to IgE concentrations of <100, 
      >100, and <260 kU/L), as shown by significant correlation coefficients and 
      regression slopes. Our findings show that IgE levels in infants of mothers who 
      presented serum IgE levels of >100 kU/L exceeded the norm during the 1st year of 
      life, in the absence of overt atopic disease. It seems useful to consider 
      different categories of infants, as a function of their mothers' IgE, to plan a 
      particular follow-up for children in higher risk classes.
FAU - De Amici, Mara
AU  - De Amici M
AD  - Department of Pediatrics, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy.
FAU - Belloni, Cesare
AU  - Belloni C
FAU - De Silvestri, Annalisa
AU  - De Silvestri A
FAU - Perotti, Francesca
AU  - Perotti F
FAU - Quaglini, Silvana
AU  - Quaglini S
FAU - Ciprandi, Giorgio
AU  - Ciprandi G
FAU - Marseglia, Gianluigi
AU  - Marseglia G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Infant
MH  - Infant, Newborn
MH  - Pregnancy
EDAT- 2008/02/28 09:00
MHDA- 2008/06/06 09:00
CRDT- 2008/02/28 09:00
PHST- 2008/02/28 09:00 [pubmed]
PHST- 2008/06/06 09:00 [medline]
PHST- 2008/02/28 09:00 [entrez]
AID - 10.2500/aap2008.29.3081 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2008 Jan-Feb;29(1):74-7. doi: 10.2500/aap2008.29.3081.