PMID- 18303581
OWN - NLM
STAT- MEDLINE
DCOM- 20080409
LR  - 20151119
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 19
IP  - 3
DP  - 2008 Feb 12
TI  - Effects of 4-methylcatechol on spatial memory and depression.
PG  - 355-9
LID - 10.1097/WNR.0b013e3282f519c7 [doi]
AB  - Emerging evidence suggests that dementia and depression, two clinical symptoms 
      commonly associated, share the disorder of neuroplasticity in their 
      neural/molecular pathology. Maintenance of sufficient neurostructural 
      remodelling/neurotrophic activity may be central to cognition/antidementia and a 
      balanced mood. Here, we show that intra-cerebroventricular (i.c.v.) 
      4-methylcatechol (4-MC), a stimulator of brain-derived neurotrophic factor (BDNF) 
      expression and an indirect PKC activator significantly enhanced spatial learning 
      and memory in rats and produced an antidepressant effect. Both effects were 
      eliminated by co-administration of function-blocking anti-BDNF antibody. These 
      results further support the hypothesis that memory processing and mood regulation 
      share common mechanisms and thus therapeutic targets. BDNF enhancers may 
      represent one of the new drug strategies in the fighting against depression 
      associated with memory impairments.
FAU - Sun, Miao-Kun
AU  - Sun MK
AD  - Blanchette Rockefeller Neurosciences Institute, Rockville, Maryland, USA. 
      mksun@brni-jhu.org
FAU - Alkon, Daniel L
AU  - Alkon DL
LA  - eng
PT  - Journal Article
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Catechols)
RN  - 12GLI7JGB3 (4-methylcatechol)
SB  - IM
MH  - Affect/drug effects
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/physiology
MH  - Catechols/*pharmacology
MH  - Depression/*psychology
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory/*drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Space Perception/*drug effects
MH  - Swimming/psychology
EDAT- 2008/02/28 09:00
MHDA- 2008/04/10 09:00
CRDT- 2008/02/28 09:00
PHST- 2008/02/28 09:00 [pubmed]
PHST- 2008/04/10 09:00 [medline]
PHST- 2008/02/28 09:00 [entrez]
AID - 00001756-200802120-00019 [pii]
AID - 10.1097/WNR.0b013e3282f519c7 [doi]
PST - ppublish
SO  - Neuroreport. 2008 Feb 12;19(3):355-9. doi: 10.1097/WNR.0b013e3282f519c7.