PMID- 18303974
OWN - NLM
STAT- MEDLINE
DCOM- 20080924
LR  - 20211020
IS  - 0898-929X (Print)
IS  - 1530-8898 (Electronic)
IS  - 0898-929X (Linking)
VI  - 20
IP  - 8
DP  - 2008 Aug
TI  - Selective and shared contributions of the hippocampus and perirhinal cortex to 
      episodic item and associative encoding.
PG  - 1478-89
LID - 10.1162/jocn.2008.20104 [doi]
AB  - Although the general role of the medial-temporal lobe (MTL) in episodic memory is 
      well established, controversy surrounds the precise division of labor between 
      distinct MTL subregions. The perirhinal cortex (PrC) has been hypothesized to 
      support nonassociative item encoding that contributes to later familiarity, 
      whereas the hippocampus supports associative encoding that selectively 
      contributes to later recollection. However, because previous paradigms have 
      predominantly used recollection of the item context as a measure of associative 
      encoding, it remains unclear whether recollection of different kinds of episodic 
      detail depends on the same or different MTL encoding operations. In our current 
      functional magnetic resonance imaging study, we devised a subsequent memory 
      paradigm that assessed successful item encoding in addition to the encoding of 
      two distinct episodic details: an item-color and an item-context detail. 
      Hippocampal encoding activation was selectively enhanced during trials leading to 
      successful recovery of either an item-color or item-context association. 
      Moreover, the magnitude of hippocampal activation correlated with the number, and 
      not the kind, of associated details successfully bound, providing strong evidence 
      for a role of the hippocampus in domain-general associative encoding. By 
      contrast, PrC encoding activation correlated with both nonassociative item 
      encoding as well as associative item-color binding, but not with item-context 
      binding. This pattern suggests that the PrC contributions to memory encoding may 
      be domain-specific and limited to the binding of items with presented 
      item-related features. Critically, together with a separately conducted 
      behavioral study, these data raise the possibility that PrC encoding operations 
      -- in conjunction with hippocampal mechanisms -- contribute to later recollection 
      of presented item details.
FAU - Staresina, Bernhard P
AU  - Staresina BP
AD  - New York University, New York, NY 10003, USA.
FAU - Davachi, Lila
AU  - Davachi L
LA  - eng
GR  - R01 MH074692/MH/NIMH NIH HHS/United States
GR  - R01 MH074692-03/MH/NIMH NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - J Cogn Neurosci
JT  - Journal of cognitive neuroscience
JID - 8910747
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Association Learning/*physiology
MH  - *Brain Mapping
MH  - Female
MH  - Hippocampus/blood supply/*physiology
MH  - Humans
MH  - Image Processing, Computer-Assisted/methods
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Memory/*physiology
MH  - Oxygen/blood
MH  - Parahippocampal Gyrus/blood supply/*physiology
PMC - PMC2789239
MID - NIHMS157843
EDAT- 2008/02/29 09:00
MHDA- 2008/09/25 09:00
PMCR- 2009/12/05
CRDT- 2008/02/29 09:00
PHST- 2008/02/29 09:00 [pubmed]
PHST- 2008/09/25 09:00 [medline]
PHST- 2008/02/29 09:00 [entrez]
PHST- 2009/12/05 00:00 [pmc-release]
AID - 10.1162/jocn.2008.20104 [doi]
PST - ppublish
SO  - J Cogn Neurosci. 2008 Aug;20(8):1478-89. doi: 10.1162/jocn.2008.20104.