PMID- 18305218
OWN - NLM
STAT- MEDLINE
DCOM- 20080716
LR  - 20210206
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Linking)
VI  - 111
IP  - 9
DP  - 2008 May 1
TI  - Evaluation of the cytogenetic aberration pattern in amyloid light chain 
      amyloidosis as compared with monoclonal gammopathy of undetermined significance 
      reveals common pathways of karyotypic instability.
PG  - 4700-5
LID - 10.1182/blood-2007-11-122101 [doi]
AB  - Chromosomal aberrations (CAs) have emerged as important pathogenetic and 
      prognostic factors in plasma cell disorders. Using interphase fluorescence in 
      situ hybridization (FISH) analysis, we evaluated CAs in a series of 75 patients 
      with amyloid light chain amyloidosis (AL) as compared with 127 patients with 
      monoclonal gammopathy of unknown significance (MGUS). We investigated IgH 
      translocations t(11;14), t(4;14), and t(14;16) as well as gains of 1q21, 11q23, 
      and 19q13 and deletions of 8p21, 13q14, and 17p13, detecting at least one CA in 
      89% of the patients. Translocation t(11;14) was the most frequent aberration in 
      AL, with 47% versus 26% in MGUS (P = .03), and was strongly associated with the 
      lack of an intact immunoglobulin (P < .001), thus contributing to the frequent 
      light chain subtype in AL. Other frequent aberrations in AL included deletion of 
      13q14 and gain of 1q21, which were shared by MGUS at comparable frequencies. The 
      progression to multiple myeloma (MM) stage I was paralleled by an increased 
      frequency of gain of 1q21 (P = .001) in both groups. Similar branching patterns 
      were observed in an oncogenetic tree model, indicating a common mechanism of 
      underlying karyotypic instability in these plasma cell disorders.
FAU - Bochtler, Tilmann
AU  - Bochtler T
AD  - Department of Internal Medicine, Division of Hematology/Oncology, Amyloidosis 
      Clinic, University of Heidelberg, Heidelberg, Germany.
FAU - Hegenbart, Ute
AU  - Hegenbart U
FAU - Cremer, Friedrich W
AU  - Cremer FW
FAU - Heiss, Christiane
AU  - Heiss C
FAU - Benner, Axel
AU  - Benner A
FAU - Hose, Dirk
AU  - Hose D
FAU - Moos, Marion
AU  - Moos M
FAU - Bila, Jelena
AU  - Bila J
FAU - Bartram, Claus R
AU  - Bartram CR
FAU - Ho, Anthony D
AU  - Ho AD
FAU - Goldschmidt, Hartmut
AU  - Goldschmidt H
FAU - Jauch, Anna
AU  - Jauch A
FAU - Schonland, Stefan O
AU  - Schonland SO
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080227
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Immunoglobulin Light Chains)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Amyloidosis/*genetics
MH  - *Chromosome Aberrations
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Immunoglobulin Light Chains
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Monoclonal Gammopathy of Undetermined Significance/*genetics
EDAT- 2008/02/29 09:00
MHDA- 2008/07/17 09:00
CRDT- 2008/02/29 09:00
PHST- 2008/02/29 09:00 [pubmed]
PHST- 2008/07/17 09:00 [medline]
PHST- 2008/02/29 09:00 [entrez]
AID - S0006-4971(20)41160-7 [pii]
AID - 10.1182/blood-2007-11-122101 [doi]
PST - ppublish
SO  - Blood. 2008 May 1;111(9):4700-5. doi: 10.1182/blood-2007-11-122101. Epub 2008 Feb 
      27.