PMID- 18305891
OWN - NLM
STAT- MEDLINE
DCOM- 20081003
LR  - 20211020
IS  - 0300-9564 (Print)
IS  - 0300-9564 (Linking)
VI  - 115
IP  - 6
DP  - 2008 Jun
TI  - Caffeic acid attenuates the decrease of cortical BDNF transcript IV mRNA induced 
      by swim stress in wild-type but not in 5-lipoxygenase-deficient mice.
PG  - 823-7
LID - 10.1007/s00702-008-0034-7 [doi]
AB  - Caffeic acid is a natural compound that inhibits 5-lipoxygenase (5-LOX). In mice, 
      caffeic acid produces antidepressant-like effects and attenuates the decrease in 
      cortical brain-derived neurotrophic factor (BDNF) mRNA induced by forced 
      swimming. We used wild-type and 5-LOX-deficient mice and found that swimming 
      reduced the cortical content of BDNF exon IV but not exon I mRNA. The BDNF 
      transcript IV decrease was attenuated by caffeic acid in wild-type but not in 
      5-LOX-deficient mice, suggesting a role for 5-LOX in BDNF regulation.
FAU - Dzitoyeva, Svetlana
AU  - Dzitoyeva S
AD  - Department of Psychiatry, Psychiatric Institute, University of Illinois at 
      Chicago, Chicago, IL 60612, USA.
FAU - Imbesi, Marta
AU  - Imbesi M
FAU - Uz, Tolga
AU  - Uz T
FAU - Dimitrijevic, Nikola
AU  - Dimitrijevic N
FAU - Manev, Hari
AU  - Manev H
FAU - Manev, Radmila
AU  - Manev R
LA  - eng
GR  - R21 MH 074139/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20080228
PL  - Austria
TA  - J Neural Transm (Vienna)
JT  - Journal of neural transmission (Vienna, Austria : 1996)
JID - 9702341
RN  - 0 (Antidepressive Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Caffeic Acids)
RN  - 0 (RNA, Messenger)
RN  - 27YG812J1I (Arachidonic Acid)
RN  - EC 1.13.11.34 (Arachidonate 5-Lipoxygenase)
RN  - U2S3A33KVM (caffeic acid)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/metabolism/pharmacology
MH  - Antioxidants/metabolism/pharmacology
MH  - Arachidonate 5-Lipoxygenase/*genetics
MH  - Arachidonic Acid/biosynthesis
MH  - Brain Chemistry/drug effects/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Caffeic Acids/metabolism/*pharmacology
MH  - Cerebral Cortex/*drug effects/metabolism/physiopathology
MH  - Depressive Disorder/drug therapy/genetics/metabolism
MH  - Down-Regulation/drug effects/genetics
MH  - Gene Expression Regulation/drug effects/genetics
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - RNA, Messenger/*drug effects/metabolism
MH  - Stress, Psychological/*drug therapy/genetics/metabolism
MH  - Transcription, Genetic/drug effects/genetics
EDAT- 2008/02/29 09:00
MHDA- 2008/10/04 09:00
CRDT- 2008/02/29 09:00
PHST- 2007/10/26 00:00 [received]
PHST- 2008/02/07 00:00 [accepted]
PHST- 2008/02/29 09:00 [pubmed]
PHST- 2008/10/04 09:00 [medline]
PHST- 2008/02/29 09:00 [entrez]
AID - 10.1007/s00702-008-0034-7 [doi]
PST - ppublish
SO  - J Neural Transm (Vienna). 2008 Jun;115(6):823-7. doi: 10.1007/s00702-008-0034-7. 
      Epub 2008 Feb 28.