PMID- 18307080
OWN - NLM
STAT- MEDLINE
DCOM- 20080327
LR  - 20080229
IS  - 1600-0412 (Electronic)
IS  - 0001-6349 (Linking)
VI  - 87
IP  - 3
DP  - 2008
TI  - Serum levels of immunoglobulin E and the subsequent risk of pre-eclampsia: a 
      population-based study.
PG  - 373-6
LID - 10.1080/00016340701832687 [doi]
AB  - OBJECTIVE: Women with allergy may be at increased risk of developing 
      preeclampsia. We assessed serum levels of immunoglobulin E (IgE) in the first and 
      second trimester, and changes in concentration between trimesters, in relation to 
      risk of preeclampsia. MATERIALS AND METHODS: Population based case-control study 
      within a cohort of 29,948 pregnant women. We included 154 preeclampsia cases with 
      preterm delivery (before week 37) and 190 cases with delivery at term. As 
      controls, 392 women without preeclampsia were randomly selected. Levels of IgE 
      were in sera from the first and second trimester were measured and women who 
      later developed preeclampsia were compared to controls with respect to IgE 
      levels. RESULTS: Comparing the highest to the lowest quartile of IgE in the first 
      trimester, the odds ratio for preterm preeclampsia was 1.7 (95% CI, 0.9-3.1), and 
      in the second trimester, the odds ratio was 1.5 (95% CI, 0.8-2.9) for the highest 
      compared to the lowest quartile of IgE. Change in IgE between trimesters was not 
      associated with preeclampsia risk. CONCLUSION: There was a weak, however, not 
      significant association between high levels of IgE in the first and second 
      trimester and subsequent risk of preterm preeclampsia.
FAU - Eskild, Anne
AU  - Eskild A
AD  - Department of Obstetrics and Gynecology, Akershus University Hospital and the 
      Medical Faculty, University of Oslo, Norway. anne.eskild@medisin.uio.no
FAU - Nilsen, Tom Il
AU  - Nilsen TI
FAU - Jeansson, Stig
AU  - Jeansson S
FAU - Jenum, Pal A
AU  - Jenum PA
FAU - Vatten, Lars J
AU  - Vatten LJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Acta Obstet Gynecol Scand
JT  - Acta obstetricia et gynecologica Scandinavica
JID - 0370343
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Odds Ratio
MH  - Pre-Eclampsia/*blood
MH  - Pregnancy
MH  - Pregnancy Trimester, First
MH  - Pregnancy Trimester, Second
MH  - Risk Factors
EDAT- 2008/03/01 09:00
MHDA- 2008/03/28 09:00
CRDT- 2008/03/01 09:00
PHST- 2008/03/01 09:00 [pubmed]
PHST- 2008/03/28 09:00 [medline]
PHST- 2008/03/01 09:00 [entrez]
AID - 791038169 [pii]
AID - 10.1080/00016340701832687 [doi]
PST - ppublish
SO  - Acta Obstet Gynecol Scand. 2008;87(3):373-6. doi: 10.1080/00016340701832687.