PMID- 18308398
OWN - NLM
STAT- MEDLINE
DCOM- 20080811
LR  - 20211027
IS  - 1532-2742 (Electronic)
IS  - 0163-4453 (Linking)
VI  - 57
IP  - 1
DP  - 2008 Jul
TI  - Cryptococcal breast abscess in an HIV-positive patient: arguments for reviewing 
      the definition of immune reconstitution inflammatory syndrome.
PG  - 82-4
LID - 10.1016/j.jinf.2008.01.010 [doi]
AB  - Atypical manifestations of Cryptococcus neoformans disease have been reported in 
      patients with HIV-1 infection as part of the spectrum of the immune 
      reconstitution inflammatory syndrome (IRIS). We describe a cryptococcal breast 
      abscess in a patient presenting after 11 months of highly active antiretroviral 
      therapy (HAART). The arguments for and against the case being a novel 
      manifestation of IRIS are discussed. The potential hazards of using CD4 count as 
      a surrogate marker of IRIS and the danger of misdiagnosing IRIS as failure of 
      HAART are highlighted.
FAU - Haddow, Lewis J
AU  - Haddow LJ
AD  - Department of Infectious Diseases, Nelson R. Mandela School of Medicine, 
      University of KwaZulu-Natal, Private Bag 7, Congella 4013, South Africa.
FAU - Sahid, Faieza
AU  - Sahid F
FAU - Moosa, Mahomed-Yunus S
AU  - Moosa MY
LA  - eng
GR  - G0700530/MRC_/Medical Research Council/United Kingdom
PT  - Case Reports
PT  - Journal Article
DEP - 20080304
PL  - England
TA  - J Infect
JT  - The Journal of infection
JID - 7908424
SB  - IM
MH  - AIDS-Related Opportunistic Infections/complications/immunology/microbiology
MH  - Abscess/*microbiology
MH  - Antiretroviral Therapy, Highly Active
MH  - Breast/*microbiology
MH  - Cryptococcosis/*complications/*immunology/microbiology
MH  - Cryptococcus neoformans/isolation & purification
MH  - Female
MH  - HIV Infections/complications/drug therapy/*immunology
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*immunology
MH  - Middle Aged
EDAT- 2008/03/01 09:00
MHDA- 2008/08/12 09:00
CRDT- 2008/03/01 09:00
PHST- 2007/08/12 00:00 [received]
PHST- 2007/12/19 00:00 [revised]
PHST- 2008/01/16 00:00 [accepted]
PHST- 2008/03/01 09:00 [pubmed]
PHST- 2008/08/12 09:00 [medline]
PHST- 2008/03/01 09:00 [entrez]
AID - S0163-4453(08)00026-1 [pii]
AID - 10.1016/j.jinf.2008.01.010 [doi]
PST - ppublish
SO  - J Infect. 2008 Jul;57(1):82-4. doi: 10.1016/j.jinf.2008.01.010. Epub 2008 Mar 4.