PMID- 18308510
OWN - NLM
STAT- MEDLINE
DCOM- 20080812
LR  - 20211020
IS  - 1090-2139 (Electronic)
IS  - 0889-1591 (Print)
IS  - 0889-1591 (Linking)
VI  - 22
IP  - 6
DP  - 2008 Aug
TI  - The associations between psychosocial stress and the frequency of illness, and 
      innate and adaptive immune function in children.
PG  - 933-40
LID - 10.1016/j.bbi.2008.01.007 [doi]
AB  - OBJECTIVE: Family processes have a substantial impact on children's social and 
      emotional well-being, but little is known about the effects of family stress on 
      children's physical health. To begin to identify potential links between family 
      stress and health in children, we examined associations between specific aspects 
      of family psychosocial stress and the frequency of illnesses in children, 
      measures of innate and adaptive immune function, and human herpesvirus 6 (HHV-6) 
      reactivation. STUDY DESIGN: Prospective study of 169 ambulatory school-age 
      children and parents. Parents completed multiple assessments of stress at 7 
      sequential six-month visits and maintained weekly illness diaries for their 
      children over three years using a thermometer to record fever. Children had blood 
      obtained for HHV-6 and immune function studies at each visit including natural 
      killer (NK) cell function and the percentage of CD4 and CD8 cells associated with 
      immune control of cytomegalovirus (CMV). RESULTS: Parental psychiatric symptoms 
      were associated with a higher frequency of illnesses: for each 1 U increase in 
      symptom score children had an increased 1-year rate of total illnesses of 40% 
      (rate ratio, 1.40; 95% CI, 1.06-1.85) and febrile illnesses of 77% (rate ratio, 
      1.77, 95% CI, 1.00-3.13). Parental psychiatric symptom scores were also 
      associated with enhanced NK cell function (estimate, 0.15; 95% CI, 0.05-0.26) and 
      increased percentages of CD8+CD28-CD57+ cells in the blood of CMV seropositive 
      children (estimate, 2.57; 95% CI, 0.36-4.79). HHV-6 reactivation was not 
      detected. CONCLUSIONS: There is an association between specific psychosocial 
      stress exposure and rates of illness and immune function in normally developing 
      children.
FAU - Caserta, Mary T
AU  - Caserta MT
AD  - Department of Pediatrics, University of Rochester School of Medicine and 
      Dentistry, Rochester, NY 14642, USA. mary_caserta@urmc.rochester.edu
FAU - O'Connor, Thomas G
AU  - O'Connor TG
FAU - Wyman, Peter A
AU  - Wyman PA
FAU - Wang, Hongyue
AU  - Wang H
FAU - Moynihan, Jan
AU  - Moynihan J
FAU - Cross, Wendi
AU  - Cross W
FAU - Tu, Xin
AU  - Tu X
FAU - Jin, Xia
AU  - Jin X
LA  - eng
GR  - R01 HD038938-01A1/HD/NICHD NIH HHS/United States
GR  - 5 MO1 RR00044/RR/NCRR NIH HHS/United States
GR  - R01 HD 38938/HD/NICHD NIH HHS/United States
GR  - 1 UL1 RR024160-01/RR/NCRR NIH HHS/United States
GR  - M01 RR000044/RR/NCRR NIH HHS/United States
GR  - UL1 RR024160/RR/NCRR NIH HHS/United States
GR  - R01 HD038938/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20080304
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
SB  - IM
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Child
MH  - Child, Preschool
MH  - Cytomegalovirus/immunology
MH  - Family Health
MH  - Female
MH  - Herpesvirus 6, Human/immunology
MH  - Humans
MH  - Immunity/*physiology
MH  - Immunity, Innate/physiology
MH  - Killer Cells, Natural/immunology
MH  - Male
MH  - *Parent-Child Relations
MH  - Parents/*psychology
MH  - Prospective Studies
MH  - Stress, Psychological/*immunology
MH  - Surveys and Questionnaires
PMC - PMC2516370
MID - NIHMS59850
EDAT- 2008/03/01 09:00
MHDA- 2008/08/13 09:00
PMCR- 2009/08/01
CRDT- 2008/03/01 09:00
PHST- 2007/09/22 00:00 [received]
PHST- 2008/01/15 00:00 [revised]
PHST- 2008/01/15 00:00 [accepted]
PHST- 2008/03/01 09:00 [pubmed]
PHST- 2008/08/13 09:00 [medline]
PHST- 2008/03/01 09:00 [entrez]
PHST- 2009/08/01 00:00 [pmc-release]
AID - S0889-1591(08)00032-9 [pii]
AID - 10.1016/j.bbi.2008.01.007 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2008 Aug;22(6):933-40. doi: 10.1016/j.bbi.2008.01.007. Epub 
      2008 Mar 4.