PMID- 18308846
OWN - NLM
STAT- MEDLINE
DCOM- 20080808
LR  - 20211020
IS  - 0013-7227 (Print)
IS  - 1945-7170 (Electronic)
IS  - 0013-7227 (Linking)
VI  - 149
IP  - 6
DP  - 2008 Jun
TI  - Regulation of progesterone receptor expression by estradiol is dependent on age, 
      sex and region in the rat brain.
PG  - 3054-61
LID - 10.1210/en.2007-1133 [doi]
AB  - Progesterone receptor (PR) expression is highly dependent on estradiol in the 
      medial preoptic nucleus (MPN) and the ventromedial nucleus (VMN) of the adult rat 
      brain. During development, males express high levels of PR in the MPN, whereas 
      females have virtually no PR, a sex difference resulting entirely from 
      differential exposure to estradiol. Because PR is also estradiol dependent in the 
      adult VMN, the present study examined the regulation of PR immunoreactivity 
      (PRir) in the developing VMN. Surprisingly, PRir was present at high levels in 
      the VMN of both neonatal males and females. In the neonatal VMN, PR expression 
      was dependent on gonadal hormones in males but not females. When females were 
      ovariectomized and exposed to estradiol at various ages from neonatal to 
      adulthood, estradiol reliably induced PRir in the MPN at postnatal d 7 but failed 
      to induce PRir in the VMN of the same animals. Only later in development, around 
      postnatal d 14, did estradiol increase PRir in the female VMN. There appears to 
      be a developmental switch in the VMN when PR expression changes from estradiol 
      independent to estradiol dependent. Furthermore, this switch is anatomically 
      specific and does not exist in the MPN. The present results indicate that the 
      regulation of PR expression by estradiol is dependent on age, sex, and brain 
      region, suggesting that PR may play a critical but specific role in the normal 
      development of these reproductively important brain areas. In addition, the 
      neonatal female VMN may provide a unique model in which to examine the mechanisms 
      underlying the specificity of steroid-induced gene expression.
FAU - Quadros, Princy S
AU  - Quadros PS
AD  - Department of Psychology, University of Massachusetts, Amherst, Massachusetts 
      01003, USA. pquadros@nsm.umass.edu
FAU - Wagner, Christine K
AU  - Wagner CK
LA  - eng
GR  - F31 MH065874/MH/NIMH NIH HHS/United States
GR  - HD37244/HD/NICHD NIH HHS/United States
GR  - MH65874/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080228
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Receptors, Progesterone)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Aging/genetics/*physiology
MH  - Animals
MH  - Brain/growth & development/*physiology
MH  - Estradiol/*pharmacology
MH  - Female
MH  - Male
MH  - Orchiectomy
MH  - Ovariectomy
MH  - Preoptic Area/growth & development/physiology
MH  - Rats
MH  - Receptors, Progesterone/*genetics
MH  - Sex Characteristics
MH  - Ventromedial Hypothalamic Nucleus/growth & development/physiology
PMC - PMC2408808
EDAT- 2008/03/01 09:00
MHDA- 2008/08/09 09:00
PMCR- 2009/06/01
CRDT- 2008/03/01 09:00
PHST- 2008/03/01 09:00 [pubmed]
PHST- 2008/08/09 09:00 [medline]
PHST- 2008/03/01 09:00 [entrez]
PHST- 2009/06/01 00:00 [pmc-release]
AID - en.2007-1133 [pii]
AID - 4065 [pii]
AID - 10.1210/en.2007-1133 [doi]
PST - ppublish
SO  - Endocrinology. 2008 Jun;149(6):3054-61. doi: 10.1210/en.2007-1133. Epub 2008 Feb 
      28.