PMID- 18309438
OWN - NLM
STAT- MEDLINE
DCOM- 20151221
LR  - 20240317
IS  - 1760-4788 (Electronic)
IS  - 1279-7707 (Linking)
VI  - 12
IP  - 3
DP  - 2008 Mar
TI  - Serum brain-derived neurotrophic factor is associated with reduced appetite in 
      healthy older adults.
PG  - 183-5
AB  - OBJECTIVE: Loss of appetite and body mass are common in older adults and are 
      associated with negative consequences. Research indicates that these processes 
      likely involve increases in serum brain-derived neurotrophic factor (BDNF). 
      Animal and human models demonstrate that BDNF may serve a regulatory function in 
      food intake, but no study has addressed the possibility that BDNF may be involved 
      in appetite reduction and loss of body mass in older adults. DESIGN AND 
      PARTICIPANTS: 34 older adults without significant neurological or psychiatric 
      history underwent fasting blood draw and measurement of body composition. 
      Appetite and eating behavior were assessed by questionnaire and related to serum 
      BDNF levels. RESULTS: Partial correlations showed serum BDNF levels were 
      inversely related to appetite (r = -.38, p = .02). No significant correlations 
      emerged between serum BDNF and age, diet, or body composition. CONCLUSIONS: The 
      current study extends past work and shows that BDNF is associated with appetite 
      in healthy older adults. Further work is needed to clarify mechanisms for these 
      findings, particularly prospective studies.
FAU - Stanek, K
AU  - Stanek K
AD  - Department of Psychology, Kent State University, Kent, OH, USA.
FAU - Gunstad, J
AU  - Gunstad J
FAU - Leahey, T
AU  - Leahey T
FAU - Glickman, E
AU  - Glickman E
FAU - Alexander, T
AU  - Alexander T
FAU - Spitznagel, M B
AU  - Spitznagel MB
FAU - Juvancic Heltzel, J
AU  - Juvancic Heltzel J
FAU - Murray, L
AU  - Murray L
LA  - eng
PT  - Journal Article
PL  - France
TA  - J Nutr Health Aging
JT  - The journal of nutrition, health & aging
JID - 100893366
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/blood
MH  - Animals
MH  - Appetite/*physiology
MH  - Body Composition
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Diet
MH  - Eating
MH  - Fasting
MH  - Female
MH  - *Health
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2008/03/01 09:00
MHDA- 2015/12/22 06:00
CRDT- 2008/03/01 09:00
PHST- 2008/03/01 09:00 [pubmed]
PHST- 2015/12/22 06:00 [medline]
PHST- 2008/03/01 09:00 [entrez]
AID - S1279-7707(23)02041-9 [pii]
AID - 10.1007/BF02982616 [doi]
PST - ppublish
SO  - J Nutr Health Aging. 2008 Mar;12(3):183-5. doi: 10.1007/BF02982616.