PMID- 18309686
OWN - NLM
STAT- MEDLINE
DCOM- 20080507
LR  - 20211020
IS  - 1226-3303 (Print)
IS  - 2005-6648 (Electronic)
IS  - 1226-3303 (Linking)
VI  - 22
IP  - 4
DP  - 2007 Dec
TI  - Differences in insulin sensitivity and secretory capacity based on OGTT in 
      subjects with impaired glucose regulation.
PG  - 270-4
AB  - BACKGROUND: This study examined whether defects in insulin secretion contribute 
      to the development and progression of type 2 diabetes mellitus (T2DM). METHODS: 
      Plasma insulin and glucose were measured after a glucose tolerance test to 
      calculate the insulinogenic index (IGI) and the HOMA-IR Homeostasis model 
      assessment of insulin resistance in subjects with normal glucose tolerance (NGT), 
      prediabetes (preDM, n = 49), and T2DM patients with disease duration < 1 year (n 
      = 84), 1 approximately 5 years (n = 45), or > 5 years (n = 37). Plasma proinsulin 
      and adiponectin levels were also measured as a parameter of insulin secretion and 
      resistance. RESULTS: The mean HOMA-IR increased and the adiponectin levels 
      decreased relative to the deterioration of glucose tolerance in NGT and preDM 
      subjects. However, differences in the HOMA-IR were not related to disease 
      duration in T2DM subjects. The mean IGI was similar in NGT and preDM subjects, 
      but there were significant deteriorations in IGI relative to the duration of 
      diabetes. CONCLUSIONS: Defects in both insulin sensitivity and insulin secretion 
      contribute to T2DM, but decreased insulin secretion may be more important in the 
      development and progression of T2DM.
FAU - Rhee, Sang Youl
AU  - Rhee SY
AD  - Department of Endocrinology and Metabolism, Kyung Hee University School of 
      Medicine, Seoul, Korea.
FAU - Kwon, Mi Kwang
AU  - Kwon MK
FAU - Park, Byong-Jo
AU  - Park BJ
FAU - Chon, Suk
AU  - Chon S
FAU - Jeong, In-Kyung
AU  - Jeong IK
FAU - Oh, Seungjoon
AU  - Oh S
FAU - Ahn, Kyu Jeung
AU  - Ahn KJ
FAU - Chung, Ho Yeon
AU  - Chung HY
FAU - Kim, Sung Woon
AU  - Kim SW
FAU - Kim, Jin-Woo
AU  - Kim JW
FAU - Kim, Young Seol
AU  - Kim YS
FAU - Woo, Jeong-Taek
AU  - Woo JT
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - Korean J Intern Med
JT  - The Korean journal of internal medicine
JID - 8712418
RN  - 0 (Insulin)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Disease Outbreaks
MH  - Female
MH  - *Glucose Tolerance Test
MH  - Health Status Indicators
MH  - Humans
MH  - Insulin/*metabolism
MH  - *Insulin Resistance
MH  - Insulin Secretion
MH  - Male
MH  - Middle Aged
PMC - PMC2687668
EDAT- 2008/03/04 09:00
MHDA- 2008/05/08 09:00
PMCR- 2007/12/01
CRDT- 2008/03/04 09:00
PHST- 2008/03/04 09:00 [pubmed]
PHST- 2008/05/08 09:00 [medline]
PHST- 2008/03/04 09:00 [entrez]
PHST- 2007/12/01 00:00 [pmc-release]
AID - 10.3904/kjim.2007.22.4.270 [doi]
PST - ppublish
SO  - Korean J Intern Med. 2007 Dec;22(4):270-4. doi: 10.3904/kjim.2007.22.4.270.