PMID- 18310464
OWN - NLM
STAT- MEDLINE
DCOM- 20080812
LR  - 20211020
IS  - 1530-6860 (Electronic)
IS  - 0892-6638 (Linking)
VI  - 22
IP  - 7
DP  - 2008 Jul
TI  - Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intake.
PG  - 2393-404
LID - 10.1096/fj.07-099135 [doi]
AB  - We recently identified brain-derived neurotrophic factor (BDNF) in the dorsal 
      striatum to be a major component of a homeostatic pathway controlling ethanol 
      consumption. We hypothesized that ethanol-mediated activation of the BDNF 
      signaling cascade is required for the ethanol-related function of the 
      neurotrophic factor. Here, we demonstrate that exposure of striatal neurons to 
      ethanol results in the activation of the BDNF receptor TrkB, leading to the 
      activation of the mitogen-activated protein kinase (MAP kinase) signaling pathway 
      and the subsequent increase in the expression of preprodynorphin (Pdyn) via BDNF. 
      Finally, we show that activation of the dynorphin receptor, the kappa opioid 
      receptor (KOR), is required for the BDNF-mediated decrease in ethanol intake, 
      illustrating a function of dynorphin in BDNF's homeostatic control of ethanol 
      consumption. Taken together, these results demonstrate that BDNF regulates 
      ethanol intake by initiation of MAP kinase signaling and the ensuing production 
      of downstream gene products, including Pdyn.
FAU - Logrip, Marian L
AU  - Logrip ML
AD  - Ernest Gallo Research Center, Emeryville, CA 94608, USA.
FAU - Janak, Patricia H
AU  - Janak PH
FAU - Ron, Dorit
AU  - Ron D
LA  - eng
GR  - F31 AA015462/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080229
PL  - United States
TA  - FASEB J
JT  - FASEB journal : official publication of the Federation of American Societies for 
      Experimental Biology
JID - 8804484
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 74913-18-1 (Dynorphins)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
SB  - IM
CIN - FASEB J. 2008 Jul;22(7):2113; author reply 2113-4. PMID: 18593720
MH  - Alcohol Drinking/*physiopathology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cell Culture Techniques
MH  - Corpus Striatum/physiology/*physiopathology
MH  - Disease Models, Animal
MH  - Dynorphins/*physiology
MH  - Extracellular Signal-Regulated MAP Kinases/metabolism
MH  - Gene Expression Regulation
MH  - Homeostasis
MH  - Humans
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neurons/cytology/pathology/*physiology
MH  - Rats
MH  - Rats, Long-Evans
MH  - Rats, Sprague-Dawley
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2008/03/04 09:00
MHDA- 2008/08/13 09:00
CRDT- 2008/03/04 09:00
PHST- 2008/03/04 09:00 [pubmed]
PHST- 2008/08/13 09:00 [medline]
PHST- 2008/03/04 09:00 [entrez]
AID - fj.07-099135 [pii]
AID - 10.1096/fj.07-099135 [doi]
PST - ppublish
SO  - FASEB J. 2008 Jul;22(7):2393-404. doi: 10.1096/fj.07-099135. Epub 2008 Feb 29.