PMID- 18311782
OWN - NLM
STAT- MEDLINE
DCOM- 20080530
LR  - 20211203
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 112
IP  - 8
DP  - 2008 Apr 15
TI  - Subclinical late cardiac toxicity in childhood cancer survivors: impact on 
      self-reported health.
PG  - 1835-44
LID - 10.1002/cncr.23378 [doi]
AB  - BACKGROUND: The authors analyzed how self-reported health and self-reported 
      modified New York Heart Association (NYHA) cardiac function scores were related 
      to cardiac systolic function, cardiac risk factors, and cancer treatment history 
      in childhood cancer survivors who reported no symptoms of cardiac disease. 
      METHODS: Long-term survivors of pediatric cancer who were treated between 1971 
      and 1995 (current ages, 16-39.7 years) underwent noninvasive clinical and 
      laboratory cardiac risk evaluation and responded to selected subscales of the 
      Medical Outcomes Study 36-item Short Form Health Survey. Results were compared 
      with survivor history of anthracycline therapy alone or with radiotherapy (n=127 
      patients; mean, 10 years after diagnosis) versus no anthracycline therapy (n=32 
      patients; mean, 11 years after diagnosis). RESULTS: Sex, current age, highest 
      school grade completed, race, age at diagnosis, diagnostic group, years off 
      therapy, fractional shortening (FS), heart rate, and smoking status were found to 
      be independently predictive of self-reported health. Interaction between female 
      sex and higher low-density lipoprotein values and between diagnosis and abnormal 
      FS variably predicted low reported vitality and low reported modified New York 
      Heart Association (NYHA) scores. Echocardiographic findings, cardiac risk 
      factors, and treatment history explained 13% to 28% of the variance in perceived 
      health and self-reported modified NYHA scores. CONCLUSIONS: Systolic function and 
      cardiac risk factors were linked to lower self-reported health and NYHA scores 
      even in the absence of clinically evident cardiotoxicity.
FAU - Cox, Cheryl L
AU  - Cox CL
AD  - Department of Epidemiology and Cancer Control, St. Jude Children's Research 
      Hospital, Memphis, Tennessee 38105-2794, USA. cheryl.cox@stjude.org
FAU - Rai, Shesh N
AU  - Rai SN
FAU - Rosenthal, David
AU  - Rosenthal D
FAU - Phipps, Sean
AU  - Phipps S
FAU - Hudson, Melissa M
AU  - Hudson MM
LA  - eng
GR  - CA 21765/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - 0 (Anthracyclines)
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Cholesterol, LDL)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Anthracyclines/adverse effects
MH  - Antibiotics, Antineoplastic/adverse effects
MH  - Antineoplastic Agents/*adverse effects
MH  - *Attitude to Health
MH  - Cholesterol, LDL/blood
MH  - Echocardiography
MH  - Educational Status
MH  - Female
MH  - Heart/*drug effects/radiation effects
MH  - Heart Rate/drug effects/radiation effects
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Neoplasms/*drug therapy/radiotherapy
MH  - Racial Groups
MH  - Radiotherapy, Adjuvant/adverse effects
MH  - Risk Assessment
MH  - Sex Factors
MH  - Smoking
MH  - *Survivors
MH  - Systole/drug effects/radiation effects
MH  - Treatment Outcome
EDAT- 2008/03/04 09:00
MHDA- 2008/05/31 09:00
CRDT- 2008/03/04 09:00
PHST- 2008/03/04 09:00 [pubmed]
PHST- 2008/05/31 09:00 [medline]
PHST- 2008/03/04 09:00 [entrez]
AID - 10.1002/cncr.23378 [doi]
PST - ppublish
SO  - Cancer. 2008 Apr 15;112(8):1835-44. doi: 10.1002/cncr.23378.