PMID- 18312478
OWN - NLM
STAT- MEDLINE
DCOM- 20080807
LR  - 20151119
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 71
IP  - 5
DP  - 2008 May
TI  - Multiple sclerosis in Gypsies from southern Spain: prevalence, mitochondrial DNA 
      haplogroups and HLA class II association.
PG  - 426-33
LID - 10.1111/j.1399-0039.2008.01016.x [doi]
AB  - Occasional reports have mentioned the prevalence of multiple sclerosis (MS) among 
      Gypsies, and no studies have examined to date the prevalence of MS or human 
      leukocyte antigen (HLA) genetics associations in the Spanish Gypsy population. We 
      decided to study the prevalence, mitochondrial DNA (mtDNA) haplogroups and HLA 
      class II distribution among gypsies with MS in southern Spain. We searched for 
      Gypsy MS patients and studied HLA class II alleles by polymerase chain reaction 
      with sequence-specific oligonucleotide (PCR/SSO) probe hybridization or 
      sequence-specific primers amplification. An additional study of the mtDNA 
      haplogroups by sequencing of the hypervariable segments of the control region was 
      also performed to provide details of their ethnic origin. Estimated prevalence of 
      MS in the Gypsy population in Malaga was 52/100,000. No significant differences 
      were found in mtDNA between Gypsy MS patients and Gypsy controls. DRB1*1501, 
      DQB1*0602 and DQB1*0608 alleles were the only positive HLA association with MS. 
      The Gypsies in our series have the same anthropological origin as other European 
      gypsy groups, as shown by mtDNA haplogroups. Although interpreted with great 
      caution because of the small sample size, we found that the prevalence of MS in 
      Gypsies in Malaga is not as low as that in Central Europe, although it is 
      significantly less than that found in Caucasians from Spain (75-79/100,000). 
      DQB1*0602 was the strongest positive association found with Gypsy MS patients, 
      and DRB1*1501-DQB1*0602 was the most frequent haplotype in this group.
FAU - Fernandez, O
AU  - Fernandez O
AD  - Institute of Clinical Neurosciences, Hospital Regional Universitario Carlos Haya, 
      Malaga, Spain. oscar.fernandez.sspa@juntadeandalucia.es
FAU - Fernandez, V
AU  - Fernandez V
FAU - Martinez-Cabrera, V
AU  - Martinez-Cabrera V
FAU - Mayorga, C
AU  - Mayorga C
FAU - Alonso, A
AU  - Alonso A
FAU - Leon, A
AU  - Leon A
FAU - Arnal, C
AU  - Arnal C
FAU - Hens, M
AU  - Hens M
FAU - Luque, G
AU  - Luque G
FAU - de Ramon, E
AU  - de Ramon E
FAU - Caballero, A
AU  - Caballero A
FAU - Leyva, L
AU  - Leyva L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20080228
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (DNA, Mitochondrial)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (Membrane Glycoproteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - DNA, Mitochondrial/*genetics
MH  - Female
MH  - *Genes, MHC Class II
MH  - Genetic Predisposition to Disease
MH  - Genetics, Population
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Membrane Glycoproteins/*genetics
MH  - Middle Aged
MH  - Mitochondria/genetics
MH  - Multiple Sclerosis/epidemiology/*genetics
MH  - Prevalence
MH  - Roma/*genetics
MH  - Spain/epidemiology
EDAT- 2008/03/04 09:00
MHDA- 2008/08/08 09:00
CRDT- 2008/03/04 09:00
PHST- 2008/03/04 09:00 [pubmed]
PHST- 2008/08/08 09:00 [medline]
PHST- 2008/03/04 09:00 [entrez]
AID - TAN1016 [pii]
AID - 10.1111/j.1399-0039.2008.01016.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2008 May;71(5):426-33. doi: 10.1111/j.1399-0039.2008.01016.x. 
      Epub 2008 Feb 28.