PMID- 18312480
OWN - NLM
STAT- MEDLINE
DCOM- 20080807
LR  - 20111117
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 71
IP  - 5
DP  - 2008 May
TI  - Evidence for HLA class II susceptible and protective haplotypes for osteomyelitis 
      in pediatric patients with sickle cell anemia.
PG  - 453-7
LID - 10.1111/j.1399-0039.2008.01012.x [doi]
AB  - We investigated the association of human leukocyte antigen (HLA) class II alleles 
      and haplotypes with the pathogenesis of sickle cell anemia (SCA) osteomyelitis. 
      SCA patients comprised 42 patients with osteomyelitis and 150 patients without 
      osteomyelitis; HLA-DRB1* and HLA-DQB1* genotyping was performed by polymerase 
      chain reaction-sequence-specific priming (SSP). DRB1*100101 (P value corrected 
      for the number of different alleles tested, Pc=0.003) was positively associated 
      with osteomyelitis. At the haplotype level, DRB1*100101-DQB1*050101 (Pc=0.001) 
      was more prevalent among patients, while DRB1*030101-DQB1*0201 (Pc=0.020) and 
      DRB1*040101-DQB1*0302 (Pc=0.039) were more prevalent among SCA controls, thereby 
      conferring disease susceptibility or protection to these haplotypes, 
      respectively. These results show that specific HLA haplotypes influence SCA 
      osteomyelitis risk and that specific HLA types may serve as markers for 
      identifying SCA patients at high risk for osteomyelitis.
FAU - Al-Ola, K
AU  - Al-Ola K
AD  - Department of Pediatrics, Salmaniya Medical Complex, Manama, Bahrain.
FAU - Mahdi, N
AU  - Mahdi N
FAU - Al-Subaie, A M
AU  - Al-Subaie AM
FAU - Ali, M E
AU  - Ali ME
FAU - Al-Absi, I K
AU  - Al-Absi IK
FAU - Almawi, W Y
AU  - Almawi WY
LA  - eng
PT  - Journal Article
DEP - 20080228
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Alleles
MH  - Anemia, Sickle Cell/*genetics
MH  - Child
MH  - Female
MH  - Gene Frequency
MH  - *Genes, MHC Class II
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Osteomyelitis/*genetics
EDAT- 2008/03/04 09:00
MHDA- 2008/08/08 09:00
CRDT- 2008/03/04 09:00
PHST- 2008/03/04 09:00 [pubmed]
PHST- 2008/08/08 09:00 [medline]
PHST- 2008/03/04 09:00 [entrez]
AID - TAN1012 [pii]
AID - 10.1111/j.1399-0039.2008.01012.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2008 May;71(5):453-7. doi: 10.1111/j.1399-0039.2008.01012.x. 
      Epub 2008 Feb 28.