PMID- 18312755
OWN - NLM
STAT- MEDLINE
DCOM- 20080328
LR  - 20151119
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 101
IP  - 4
DP  - 2008 Feb 15
TI  - Comparison of usefulness of C-reactive protein versus white blood cell count to 
      predict outcome after primary percutaneous coronary intervention for ST elevation 
      myocardial infarction.
PG  - 446-51
LID - 10.1016/j.amjcard.2007.09.088 [doi]
AB  - White blood cell (WBC) count and high-sensitive C-reactive protein (hs-CRP) are 
      both used as markers of inflammation and prognosis after an ST elevation 
      myocardial infarction (STEMI), but it is unknown whether they have independent 
      prognostic value. We investigated the association and independent prognostic 
      importance of WBC and hs-CRP after STEMI. In this subanalysis of the On-TIME 
      trial, in 490 of 507 (97%) patients, either WBC count or CRP, and in 362 (71%) 
      patients, both WBC count and CRP, were measured on admission before primary 
      percutaneous coronary intervention. There was no significant correlation between 
      WBC count and CRP (R = 0.080). Higher levels of CRP were associated with a 
      reinfarction or death within 1 year (mean hs-CRP 14.2 +/- 20.4 vs 6.1 +/- 14.2, p 
      = 0.006), but CRP was not associated with enzymatic infarct size (lactate 
      dehydrogenase, LDHQ48) or left ventricular ejection fraction. A higher baseline 
      WBC count was associated with larger LDHQ48 and lower left ventricular ejection 
      fraction but not with 1-year reinfarction or death. In conclusion, although both 
      WBC count and CRP are markers of inflammation and predictors of outcome after 
      STEMI, we did not find a correlation between baseline WBC count and CRP levels in 
      patients treated with primary percutaneous coronary intervention for STEMI. The 
      mechanisms by which WBC counts predict outcome were related to myocardial infarct 
      size whereas CRP were not.
FAU - Smit, Jaap Jan J
AU  - Smit JJ
AD  - Department of Cardiology, Isala Klinieken, Zwolle, the Netherlands.
FAU - Ottervanger, Jan Paul
AU  - Ottervanger JP
FAU - Slingerland, Robbert J
AU  - Slingerland RJ
FAU - Kolkman, J J Evelien
AU  - Kolkman JJ
FAU - Suryapranata, Harry
AU  - Suryapranata H
FAU - Hoorntje, Jan C A
AU  - Hoorntje JC
FAU - Dambrink, Jan-Henk E
AU  - Dambrink JH
FAU - Gosselink, A T Marcel
AU  - Gosselink AT
FAU - de Boer, Menko-Jan
AU  - de Boer MJ
FAU - Zijlstra, Felix
AU  - Zijlstra F
FAU - van 't Hof, Arnoud W J
AU  - van 't Hof AW
CN  - On-TIME Study Group
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Biomarkers)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - *Angioplasty, Balloon, Coronary
MH  - Biomarkers/blood
MH  - C-Reactive Protein/*analysis
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Hypotension/epidemiology
MH  - L-Lactate Dehydrogenase/blood
MH  - *Leukocyte Count
MH  - Male
MH  - Multivariate Analysis
MH  - Myocardial Infarction/*blood/mortality/*therapy
MH  - Prospective Studies
MH  - Recurrence
MH  - Stroke Volume
EDAT- 2008/03/04 09:00
MHDA- 2008/03/29 09:00
CRDT- 2008/03/04 09:00
PHST- 2007/08/08 00:00 [received]
PHST- 2007/09/24 00:00 [revised]
PHST- 2007/09/24 00:00 [accepted]
PHST- 2008/03/04 09:00 [pubmed]
PHST- 2008/03/29 09:00 [medline]
PHST- 2008/03/04 09:00 [entrez]
AID - S0002-9149(07)02028-0 [pii]
AID - 10.1016/j.amjcard.2007.09.088 [doi]
PST - ppublish
SO  - Am J Cardiol. 2008 Feb 15;101(4):446-51. doi: 10.1016/j.amjcard.2007.09.088.