PMID- 18313764
OWN - NLM
STAT- MEDLINE
DCOM- 20080826
LR  - 20080425
IS  - 0165-2427 (Print)
IS  - 0165-2427 (Linking)
VI  - 123
IP  - 1-2
DP  - 2008 May 15
TI  - Molecular pathogenesis of feline leukemia virus-induced malignancies: insertional 
      mutagenesis.
PG  - 138-43
LID - 10.1016/j.vetimm.2008.01.019 [doi]
AB  - Feline leukemia virus (FeLV), which is subclassified into three subgroups of A, B 
      and C, is a pathogenic retrovirus in cats. FeLV-A is minimally pathogenic, FeLV-C 
      can cause pure red cell aplasia, and FeLV-B is associated with a variety of 
      pathogenic properties such as lymphoma, leukemia and anemia. FeLV-induced 
      neoplasms are caused, at least in part, by somatically acquired insertional 
      mutagenesis in which the integrated provirus may activate a proto-oncogene or 
      disrupt a tumor suppressor gene. The common integration sites for FeLV have been 
      identified in six loci with feline lymphomas: c-myc, flvi-1, flvi-2 (contains 
      bmi-1), fit-1, pim-1 and flit-1. Oncogenic association of the loci includes that 
      c-myc is known as a proto-oncogene, bmi-1 and pim-1 have been recognized as 
      myc-collaborators, fit-1 appears to be closely linked to myb, and flit-1 
      insertion is shown to be associated with over-expression of a cellular gene, e.g. 
      ACVRL1. Thus, identification of common integration sites for FeLV is a tenable 
      model to clarify oncogenesis. Recent advances in molecular biology and 
      cytogenetics have developed to rapidly detect numbers of retroviral integration 
      sites by genome-wide large-scale analyses. Especially, polymerase chain reaction 
      (PCR)-based strategies and chromosome analyses with fluorescence in situ 
      hybridization (FISH) will be applicable for studies on FeLV.
FAU - Fujino, Yasuhito
AU  - Fujino Y
AD  - Department of Veterinary Internal Medicine, Graduate School of Agricultural and 
      Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, 
      Japan. afujino@mail.ecc.u-tokyo.ac.jp
FAU - Ohno, Koichi
AU  - Ohno K
FAU - Tsujimoto, Hajime
AU  - Tsujimoto H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20080119
PL  - Netherlands
TA  - Vet Immunol Immunopathol
JT  - Veterinary immunology and immunopathology
JID - 8002006
SB  - IM
MH  - Animals
MH  - Cat Diseases/*virology
MH  - Cats
MH  - Genome, Viral
MH  - Leukemia Virus, Feline/*genetics
MH  - Mutagenesis, Insertional
MH  - Proviruses/*genetics
MH  - Retroviridae Infections/*veterinary/virology
MH  - Tumor Virus Infections/*veterinary/virology
RF  - 81
EDAT- 2008/03/04 09:00
MHDA- 2008/08/30 09:00
CRDT- 2008/03/04 09:00
PHST- 2008/03/04 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/03/04 09:00 [entrez]
AID - S0165-2427(08)00027-5 [pii]
AID - 10.1016/j.vetimm.2008.01.019 [doi]
PST - ppublish
SO  - Vet Immunol Immunopathol. 2008 May 15;123(1-2):138-43. doi: 
      10.1016/j.vetimm.2008.01.019. Epub 2008 Jan 19.