PMID- 18313855
OWN - NLM
STAT- MEDLINE
DCOM- 20080721
LR  - 20131121
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 152
IP  - 3
DP  - 2008 Mar 27
TI  - Cortical expression of brain derived neurotrophic factor and type-1 cannabinoid 
      receptor after striatal excitotoxic lesions.
PG  - 734-40
LID - 10.1016/j.neuroscience.2007.11.044 [doi]
AB  - An involvement of one particular neurotrophin, namely, the brain-derived 
      neurotrophic factor (BDNF), has been demonstrated in the pathophysiology 
      Huntington's disease. Type-1 cannabinoid (CB1) receptor has been postulated to 
      upregulate BDNF gene transcription. To better understand the relationship between 
      CB1 and BDNF levels in a situation where the striatum is degenerating, we 
      studied, by dual label immunofluorescence, the distribution of CB1 and BDNF in 
      cortical neurons projecting to the striatum in our rat quinolinic acid model of 
      striatal excitotoxicity. We completed our study with quantitative analyses of 
      BDNF protein levels and CB1 binding activity in the cortex. We show that, 2 weeks 
      post lesion, cortical neurons contain more BDNF compared with controls and to 
      earlier time points. Such BDNF up-regulation coincides with a higher binding 
      activity and an increased protein expression of CB1. We suggest that after 
      excitotoxic lesions, CB1 might, at least transiently, upregulate BDNF in the 
      attempt to rescue striatal neurons from degeneration.
FAU - De March, Z
AU  - De March Z
AD  - Laboratory of Neuroanatomy, Santa Lucia Foundation IRCCS at the European Center 
      for Brain research, Via del Fosso Fiorano 64, 00143 Rome, Italy.
FAU - Zuccato, C
AU  - Zuccato C
FAU - Giampa, C
AU  - Giampa C
FAU - Patassini, S
AU  - Patassini S
FAU - Bari, M
AU  - Bari M
FAU - Gasperi, V
AU  - Gasperi V
FAU - De Ceballos, M L
AU  - De Ceballos ML
FAU - Bernardi, G
AU  - Bernardi G
FAU - Maccarrone, M
AU  - Maccarrone M
FAU - Cattaneo, E
AU  - Cattaneo E
FAU - Fusco, F R
AU  - Fusco FR
LA  - eng
PT  - Journal Article
DEP - 20071208
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neurotoxins)
RN  - 0 (Receptor, Cannabinoid, CB1)
RN  - F6F0HK1URN (Quinolinic Acid)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cell Communication/physiology
MH  - Cell Survival/physiology
MH  - Cerebral Cortex/*metabolism/physiopathology
MH  - Corpus Striatum/drug effects/*metabolism/physiopathology
MH  - Cytoprotection/physiology
MH  - Disease Models, Animal
MH  - Fluorescent Antibody Technique
MH  - Huntington Disease/metabolism/physiopathology
MH  - Male
MH  - Nerve Degeneration/chemically induced/metabolism/physiopathology
MH  - Neurotoxins
MH  - Protein Binding
MH  - Quinolinic Acid
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, Cannabinoid, CB1/*metabolism
MH  - Time Factors
MH  - Up-Regulation/physiology
EDAT- 2008/03/04 09:00
MHDA- 2008/07/22 09:00
CRDT- 2008/03/04 09:00
PHST- 2007/08/24 00:00 [received]
PHST- 2007/10/23 00:00 [revised]
PHST- 2007/11/28 00:00 [accepted]
PHST- 2008/03/04 09:00 [pubmed]
PHST- 2008/07/22 09:00 [medline]
PHST- 2008/03/04 09:00 [entrez]
AID - S0306-4522(07)01529-1 [pii]
AID - 10.1016/j.neuroscience.2007.11.044 [doi]
PST - ppublish
SO  - Neuroscience. 2008 Mar 27;152(3):734-40. doi: 10.1016/j.neuroscience.2007.11.044. 
      Epub 2007 Dec 8.