PMID- 18314120
OWN - NLM
STAT- MEDLINE
DCOM- 20090319
LR  - 20190816
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 91
IP  - 3
DP  - 2009 Mar
TI  - Expression of interleukin-8 and monocyte chemotactic protein 1 in women with 
      endometriosis.
PG  - 687-93
LID - 10.1016/j.fertnstert.2007.12.067 [doi]
AB  - OBJECTIVE: To investigate the expression and localization of interleukin-8 (IL-8) 
      and monocyte chemotactic protein 1 (MCP-1) in women with and without 
      endometriosis. DESIGN: Comparative immunohistochemical study. SETTING: Academic 
      medical center. PATIENT(S): Ectopic (n = 24) and homologous eutopic endometrium 
      (n = 24) from women with endometriosis and endometrium from women without 
      endometriosis (n = 27) were used for immunohistochemical analysis of IL-8 and 
      MCP-1. INTERVENTION(S): Tissue sections were immunostained with antihuman IL-8 
      and MCP-1 antibodies. MAIN OUTCOME MEASURE(S): Microscopic evaluation to assess 
      the presence and localization of IL-8 and MCP-1 throughout the menstrual cycle in 
      both eutopic endometrial and endometriotic tissues of women with endometriosis 
      and comparison with normal endometrium. RESULT(S): In normal endometrium, 
      secretory phase samples expressed higher levels of epithelial IL-8 than in 
      proliferative phase samples. Epithelial MCP-1 expression was similar in both 
      proliferative and secretory phases. Proliferative phase samples showed higher 
      epithelial IL-8 and MCP-1 expressions in eutopic endometrium of women with 
      endometriosis compared with that of normal women. Immunoreactivities of both 
      chemokines were significantly increased in the epithelial cells of ectopic 
      endometrial tissues compared with those of normal endometrium. CONCLUSION(S): 
      These findings suggest that IL-8 and MCP-1 may be involved in the pathogenesis of 
      endometriosis.
FAU - Ulukus, Murat
AU  - Ulukus M
AD  - Department of Obstetrics & Gynecology, Ege University School of Medicine, 
      Bornova, Izmir, Turkey.
FAU - Ulukus, E Cagnur
AU  - Ulukus EC
FAU - Tavmergen Goker, Ege N
AU  - Tavmergen Goker EN
FAU - Tavmergen, Erol
AU  - Tavmergen E
FAU - Zheng, Wenxin
AU  - Zheng W
FAU - Arici, Aydin
AU  - Arici A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080307
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (CCL2 protein, human)
RN  - 0 (CXCL8 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Chemokine CCL2/*analysis
MH  - Endometriosis/*immunology/pathology
MH  - Endometrium/*immunology/pathology
MH  - Epithelial Cells/immunology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Interleukin-8/*analysis
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Stromal Cells/immunology
EDAT- 2008/03/04 09:00
MHDA- 2009/03/20 09:00
CRDT- 2008/03/04 09:00
PHST- 2006/11/02 00:00 [received]
PHST- 2007/12/27 00:00 [revised]
PHST- 2007/12/27 00:00 [accepted]
PHST- 2008/03/04 09:00 [pubmed]
PHST- 2009/03/20 09:00 [medline]
PHST- 2008/03/04 09:00 [entrez]
AID - S0015-0282(07)04376-2 [pii]
AID - 10.1016/j.fertnstert.2007.12.067 [doi]
PST - ppublish
SO  - Fertil Steril. 2009 Mar;91(3):687-93. doi: 10.1016/j.fertnstert.2007.12.067. Epub 
      2008 Mar 7.