PMID- 1831463
OWN - NLM
STAT- MEDLINE
DCOM- 19910926
LR  - 20190824
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 33
IP  - 3
DP  - 1991 Sep
TI  - Cytotoxic and suppressor activities in patients with HTLV-I-associated 
      myelopathy.
PG  - 199-205
AB  - Since there are several immune abnormalities and autoimmune-like features in 
      human T-cell lymphotropic virus type I (HTLV-I)-associated 
      myelopathy/HTLV-I-associated tropical spastic paraparesis (HAM/TSP), we examined 
      cytotoxic and suppressor cell functions in HAM/TSP. In this study, we assayed 
      cell-mediated cytotoxicity of CD8+ T-cell lines established from cerebrospinal 
      fluid lymphocytes of two patients with HAM and concanavalin A-induced suppressor 
      cell activities of peripheral blood lymphocytes from five patients with HAM. Our 
      study revealed that three of four CD8+ T-cell lines showed cytotoxic activities 
      against autologous CD4+ T-cell lines infected with HTLV-I, and two of the three 
      lines showed major histocompatibility complex class I-restricted cytotoxicity. We 
      also demonstrated that the concanavalin A-induced suppressor function was not 
      defective in HAM patients. Therefore, the immune abnormalities and 
      autoimmune-like features observed in HAM/TSP may not result from defective 
      cytotoxic or suppressor cell activities.
FAU - Usuku, K
AU  - Usuku K
AD  - Division of Demyelinating Disease and Aging, National Center of Neurology and 
      Psychiatry, Tokyo, Japan.
FAU - Nishizawa, M
AU  - Nishizawa M
FAU - Osame, M
AU  - Osame M
FAU - Tabira, T
AU  - Tabira T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, T-Lymphocyte)
RN  - 0 (CD4 Antigens)
RN  - 0 (CD8 Antigens)
RN  - 11028-71-0 (Concanavalin A)
SB  - IM
MH  - Adult
MH  - Antigens, CD/analysis
MH  - Antigens, Differentiation, T-Lymphocyte/analysis
MH  - CD4 Antigens/analysis
MH  - CD8 Antigens
MH  - Cell Line
MH  - Concanavalin A/pharmacology
MH  - Humans
MH  - Middle Aged
MH  - Paraparesis, Tropical Spastic/*immunology
MH  - T-Lymphocytes, Cytotoxic/immunology/*physiology
MH  - T-Lymphocytes, Regulatory/*physiology
EDAT- 1991/09/01 00:00
MHDA- 2000/06/01 00:00
CRDT- 1991/09/01 00:00
PHST- 1991/09/01 00:00 [pubmed]
PHST- 2000/06/01 00:00 [medline]
PHST- 1991/09/01 00:00 [entrez]
AID - 0165-5728(91)90107-I [pii]
AID - 10.1016/0165-5728(91)90107-i [doi]
PST - ppublish
SO  - J Neuroimmunol. 1991 Sep;33(3):199-205. doi: 10.1016/0165-5728(91)90107-i.