PMID- 18314630
OWN - NLM
STAT- MEDLINE
DCOM- 20080429
LR  - 20080304
IS  - 0070-4113 (Print)
IS  - 0070-4113 (Linking)
VI  - 91
DP  - 2007
TI  - [Gastrin cell hyperplasia associated with duodenal MEN1-related gastrinomas: 
      histopathology and genetics].
PG  - 320-9
AB  - AIMS: The identification of precursor lesions has a great impact on our 
      understanding of tumorigenesis. In this study we investigated whether 
      preneoplastic lesions can be identified in sporadic gastrinomas and in 
      gastrinomas in multiple endocrine neoplasia type 1 (MEN1) patients. These lesions 
      were tested for loss of heterozygosity (LOH) of the MEN1 gene locus on chromosome 
      11q13. MATERIAL AND METHODS: Tissue specimens from 25 patients with 
      Zollinger-Ellison syndrome (ZES) were analyzed. The MEN1 status was assessed 
      clinically and by mutational analysis. For simultaneous analysis of hormones and 
      allelic deletions a combined FISH fluorescence in situ 
      hybridization/immunofluorescence protocol was established. RESULTS: Hyperplastic 
      gastrin cell lesions were present in the nontumorous mucosa of all MEN1 patients, 
      but not in 12 patients with sporadic duodenal gastrinomas. The hyperplastic 
      gastrin cells retained both 11q13 alleles. 11q13 LOH was, however, detected in 
      duodenal gastrinomas, some as small as 300 microm in diameter, in 13 patients 
      with MEN1. CONCLUSIONS: MEN1-associated duodenal gastrinomas, but not sporadic 
      gastrinomas, are associated with gastrin cell hyperplasia. It is therefore likely 
      that hyperplastic gastrin cell lesions precede the development of MEN1-associated 
      duodenal gastrinomas. Allelic deletion of the MEN1 gene locus may reflect a 
      decisive initial event in the development of multifocal MEN1-associated 
      gastrinomas from hyperplastic gastrin cell lesions.
FAU - Anlauf, M
AU  - Anlauf M
AD  - Institut fur Pathologie, Universitatsklinikum S-H, Campus Kiel.
FAU - Perren, A
AU  - Perren A
FAU - Kloppel, G
AU  - Kloppel G
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Gastrinzellhyperplasie bei duodenalen MEN1-assoziierten Gastrinomen: 
      Histopathologie und Genetik.
PL  - Germany
TA  - Verh Dtsch Ges Pathol
JT  - Verhandlungen der Deutschen Gesellschaft fur Pathologie
JID - 7503704
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Adult
MH  - Chromosome Mapping
MH  - Duodenal Neoplasms/classification/*genetics/*pathology
MH  - Female
MH  - Humans
MH  - Hyperplasia
MH  - Immunohistochemistry
MH  - Loss of Heterozygosity
MH  - Male
MH  - Microscopy, Fluorescence
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/classification/*genetics/*pathology
MH  - Proto-Oncogene Proteins/*genetics
MH  - Sequence Deletion
MH  - Stomach Neoplasms/classification/genetics/pathology
EDAT- 2008/03/05 09:00
MHDA- 2008/04/30 09:00
CRDT- 2008/03/05 09:00
PHST- 2008/03/05 09:00 [pubmed]
PHST- 2008/04/30 09:00 [medline]
PHST- 2008/03/05 09:00 [entrez]
PST - ppublish
SO  - Verh Dtsch Ges Pathol. 2007;91:320-9.