PMID- 18316167
OWN - NLM
STAT- MEDLINE
DCOM- 20081014
LR  - 20150813
IS  - 0531-5565 (Print)
IS  - 0531-5565 (Linking)
VI  - 43
IP  - 4
DP  - 2008 Apr
TI  - Manipulation of caloric content but not diet composition, attenuates the deficit 
      in learning and memory of senescence-accelerated mouse strain P8.
PG  - 339-46
LID - 10.1016/j.exger.2008.01.008 [doi]
AB  - Calorie restriction (CR) is an experimental intervention in laboratory animals 
      that attenuates age-associated increases in morbidity, mortality, and functional 
      impairment. It is characterized by mild ketosis, hypoinsulinemia and 
      hypoglycemia. In this study, we examined whether metabolic simulation of CR by a 
      diet of isocaloric ketogenic or hypoinsulinemic diets ameliorated the learning 
      and memory deficit in a strain of senescence-accelerated prone mice (SAMP8), a 
      mouse model of age-dependent impairments in learning and memory. Male SAMP8 mice 
      were fed high carbohydrate (CHO), high fat (FAT), or high protein (PRO) diets 
      after weaning, and calorie intake was adjusted to 95% (sub ad libitum, sAL) or 
      70% (CR) of the mean calorie intake of control mice. At 28 weeks of age, we found 
      CR ameliorated the performance defects of SAMP8 mice in a passive avoidance task. 
      Neither FAT nor PRO diets affected performance of the task when fed sAL level, 
      although a diet of these compositions partially mimicked the serum parameters of 
      CR mice. These results suggest restriction of calorie intake is important for the 
      prevention of learning and memory deficits, and that the simulation of serum 
      changes induced by CR is not sufficient to prevent the cognitive defects of SAMP8 
      mice.
FAU - Komatsu, Toshimitsu
AU  - Komatsu T
AD  - Department of Investigative Pathology, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki, Nagasaki, Japan.
FAU - Chiba, Takuya
AU  - Chiba T
FAU - Yamaza, Haruyoshi
AU  - Yamaza H
FAU - Yamashita, Kimihiro
AU  - Yamashita K
FAU - Shimada, Atsuyoshi
AU  - Shimada A
FAU - Hoshiyama, Yasuyo
AU  - Hoshiyama Y
FAU - Henmi, Tomoko
AU  - Henmi T
FAU - Ohtani, Hiroshi
AU  - Ohtani H
FAU - Higami, Yoshikazu
AU  - Higami Y
FAU - de Cabo, Rafael
AU  - de Cabo R
FAU - Ingram, Donald K
AU  - Ingram DK
FAU - Shimokawa, Isao
AU  - Shimokawa I
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080202
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 0 (Blood Glucose)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 4Y8F71G49Q (Malondialdehyde)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Avoidance Learning/*physiology
MH  - Blood Glucose/analysis
MH  - Body Weight
MH  - Brain/pathology
MH  - Brain-Derived Neurotrophic Factor/analysis
MH  - *Caloric Restriction
MH  - Case-Control Studies
MH  - Diet
MH  - Lipid Peroxidation
MH  - Male
MH  - Malondialdehyde/analysis
MH  - Memory Disorders/*physiopathology
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Oxidative Stress
EDAT- 2008/03/05 09:00
MHDA- 2008/10/15 09:00
CRDT- 2008/03/05 09:00
PHST- 2007/11/26 00:00 [received]
PHST- 2008/01/14 00:00 [revised]
PHST- 2008/01/22 00:00 [accepted]
PHST- 2008/03/05 09:00 [pubmed]
PHST- 2008/10/15 09:00 [medline]
PHST- 2008/03/05 09:00 [entrez]
AID - S0531-5565(08)00041-7 [pii]
AID - 10.1016/j.exger.2008.01.008 [doi]
PST - ppublish
SO  - Exp Gerontol. 2008 Apr;43(4):339-46. doi: 10.1016/j.exger.2008.01.008. Epub 2008 
      Feb 2.