PMID- 18316245
OWN - NLM
STAT- MEDLINE
DCOM- 20080715
LR  - 20220408
IS  - 1388-2457 (Print)
IS  - 1388-2457 (Linking)
VI  - 119
IP  - 5
DP  - 2008 May
TI  - Brainstem auditory-evoked potential habituation and intensity-dependence related 
      to serotonin metabolism in migraine: a longitudinal study.
PG  - 1190-200
LID - 10.1016/j.clinph.2008.01.007 [doi]
AB  - OBJECTIVE: Reduced habituation and increased intensity-dependence of cortical 
      auditory-evoked potentials have been reported in migraine, but it is not known if 
      brainstem mechanisms are chiefly or partly responsible for this hypersensitivity, 
      if brainstem excitability or habituation changes across the migraine cycle, or 
      how excitability relates to symptoms and serotonin metabolism. METHODS: Brainstem 
      auditory-evoked potentials (BAEPs) to 40, 55, and 70dB binaural rarefaction 
      clicks were recorded in four blocks of 750 stimuli in a blinded longitudinal 
      study in 41 migraine patients. Serotonin was measured in a blood sample from the 
      cubital vein. The test day was classified as baseline, attack, pre-attack or 
      post-attack. RESULTS: Pre-attack BAEP changes were not found. Wave I, V and 
      interpeak III-V latency increased after the attack. III-V latency correlated with 
      headache history duration and usual headache attack duration. Habituation in wave 
      IV-V dispersion to 40dB was found in controls but not in migraine (p=0.04). 
      Serotonin correlated with BAEP amplitude in controls. Low serotonin correlated 
      with more autonomic symptoms. BAEP intensity-dependence was normal in migraine. 
      CONCLUSIONS: BAEP latencies, but not amplitude, increase temporarily after a 
      migraine attack. Abnormal habituation of brainstem wave IV-V dispersion in 
      migraine may suggest increased excitation in colliculus inferior at low sound 
      intensities, but no relation to the migraine cycle was found for wave IV-V 
      amplitude, dispersion or habituation. The correlation between BAEP amplitude and 
      serotonin was deranged in migraine patients, but reappeared temporarily within 
      72h after an attack. SIGNIFICANCE: No evidence for pre-attack brainstem auditory 
      sensitization was found in migraine. Intensity-dependence of AEP in migraine is 
      probably not a passive reflection of brainstem dysfunction. BAEP changes seem to 
      reflect a slight impact of migraine on serotonergic brainstem pathways.
FAU - Sand, Trond
AU  - Sand T
AD  - Department of Neuroscience, Norwegian University of Science and Technology, 
      Norway. trond.sand@ntnu.no
FAU - Zhitniy, Nikita
AU  - Zhitniy N
FAU - White, Linda R
AU  - White LR
FAU - Stovner, Lars Jacob
AU  - Stovner LJ
LA  - eng
PT  - Journal Article
DEP - 20080307
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Adult
MH  - Electroencephalography
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Evoked Potentials, Auditory, Brain Stem/*physiology
MH  - Female
MH  - Habituation, Psychophysiologic/*physiology
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Migraine Disorders/*blood/*physiopathology
MH  - Serotonin/*blood
EDAT- 2008/03/05 09:00
MHDA- 2008/07/17 09:00
CRDT- 2008/03/05 09:00
PHST- 2007/06/13 00:00 [received]
PHST- 2007/11/20 00:00 [revised]
PHST- 2008/01/19 00:00 [accepted]
PHST- 2008/03/05 09:00 [pubmed]
PHST- 2008/07/17 09:00 [medline]
PHST- 2008/03/05 09:00 [entrez]
AID - S1388-2457(08)00032-1 [pii]
AID - 10.1016/j.clinph.2008.01.007 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2008 May;119(5):1190-200. doi: 10.1016/j.clinph.2008.01.007. 
      Epub 2008 Mar 7.