PMID- 18317592
OWN - NLM
STAT- MEDLINE
DCOM- 20080516
LR  - 20211020
IS  - 0021-9738 (Print)
IS  - 0021-9738 (Linking)
VI  - 118
IP  - 4
DP  - 2008 Apr
TI  - Estrogen receptor beta protects against acoustic trauma in mice.
PG  - 1563-70
LID - 10.1172/JCI32796 [doi]
AB  - The hormone estradiol affects the auditory system both by itself and by its 
      interaction with neuroprotective factors. In this study, we examined the role of 
      estrogen receptors (ERs) in response to auditory trauma. We found a 
      ligand-dependent protective role for ERbeta in the auditory system by 
      investigating mice deficient in ERalpha (ERKO mice), ERbeta (BERKO mice), and 
      aromatase (ARKO mice). Basal auditory brainstem response (ABR) thresholds were 
      similar in all animals. An acoustic trauma causing a temporary hearing loss 
      raised ABR thresholds in male and female BERKO and ARKO mice compared with WT and 
      ERKO mice. The ERalpha-selective agonist, propyl(1H) 
      pyrazole-1,3,5-triyl-trisphenol (PPT), partially protected ARKO mice from trauma, 
      while the ERbeta-selective agonist, 2,3-bis (4-hydroxyphenyl)-propionitrile 
      (DPN), protected WT and ARKO mice. Immunohistochemistry and western blotting 
      confirmed the expression of ERbeta in cochlea of WT males and females. Levels of 
      brain-derived neurotrophic factor (BDNF), a neuroprotective peptide that can be 
      induced by estrogen, was lower in BERKO and ARKO mice compared with WT. DPN 
      treatment increased BDNF expression in ARKO mice. These data indicate 
      ERbeta-mediated neuroprotection involving BDNF in the auditory system of males 
      and females.
FAU - Meltser, Inna
AU  - Meltser I
AD  - Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 
      Sweden.
FAU - Tahera, Yeasmin
AU  - Tahera Y
FAU - Simpson, Evan
AU  - Simpson E
FAU - Hultcrantz, Malou
AU  - Hultcrantz M
FAU - Charitidi, Konstantina
AU  - Charitidi K
FAU - Gustafsson, Jan-Ake
AU  - Gustafsson JA
FAU - Canlon, Barbara
AU  - Canlon B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Invest
JT  - The Journal of clinical investigation
JID - 7802877
RN  - 0 (2,3-bis(4-hydroxyphenyl)-propionitrile)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogen Receptor beta)
RN  - 0 (Nitriles)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cochlea/metabolism
MH  - Estrogen Receptor alpha/agonists/deficiency/genetics/metabolism
MH  - Estrogen Receptor beta/agonists/deficiency/genetics/*metabolism
MH  - Female
MH  - Hearing Loss, Noise-Induced/drug therapy/genetics/*metabolism/pathology
MH  - Immunohistochemistry
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - Nitriles/therapeutic use
PMC - PMC2260908
EDAT- 2008/03/05 09:00
MHDA- 2008/05/17 09:00
PMCR- 2008/04/01
CRDT- 2008/03/05 09:00
PHST- 2007/05/24 00:00 [received]
PHST- 2008/01/09 00:00 [accepted]
PHST- 2008/03/05 09:00 [pubmed]
PHST- 2008/05/17 09:00 [medline]
PHST- 2008/03/05 09:00 [entrez]
PHST- 2008/04/01 00:00 [pmc-release]
AID - 32796 [pii]
AID - 10.1172/JCI32796 [doi]
PST - ppublish
SO  - J Clin Invest. 2008 Apr;118(4):1563-70. doi: 10.1172/JCI32796.