PMID- 18317925
OWN - NLM
STAT- MEDLINE
DCOM- 20081031
LR  - 20211020
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 33
IP  - 9
DP  - 2008 Sep
TI  - Brain atrophy in a murine model of chronic fatigue syndrome and beneficial effect 
      of Hochu-ekki-to (TJ-41).
PG  - 1759-67
LID - 10.1007/s11064-008-9620-1 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is associated with the main symptoms of 
      chronic fatigue syndrome (CFS) and neuron apoptosis. Nevertheless, no study has 
      been performed directly to explore the relationship between CFS, BDNF and neuron 
      apoptosis. We induced a CFS model by six injections of killed Brucella abortus 
      antigen in BALB/c mice and treated them with Hochu-ekki-to (TJ-41). Daily running 
      activity, body weight (BW), ratio of cerebral weight to BW (CW/BW) and expression 
      levels of BDNF and Bcl-2 mRNA in the hippocampus were determined. The daily 
      activity and CW/BW decreased significantly in the CFS model. BDNF and Bcl-2 mRNA 
      expression levels in the hippocampus were suppressed in the CFS model and TJ-41 
      treated mice, while no significant difference was found between them. We improved 
      a murine model to investigate the relationship between CFS and brain dysfunction. 
      In this model, reduced daily activity might have been associated with decreased 
      hippocampal BDNF mRNA expression, hippocampal apoptosis and brain atrophy. TJ-41 
      increased the daily running activity of the model, which was independent of brain 
      recovery.
FAU - Chen, Rui
AU  - Chen R
AD  - Department of General Medicine, Kanazawa Medical University, 1-1 Daigaku, 
      Uchinada-machi, Kahoku-gun, Ishikawa, 920-0293, Japan.
FAU - Moriya, Junji
AU  - Moriya J
FAU - Yamakawa, Jun-ichi
AU  - Yamakawa J
FAU - Takahashi, Takashi
AU  - Takahashi T
FAU - Li, Qian
AU  - Li Q
FAU - Morimoto, Shigeto
AU  - Morimoto S
FAU - Iwai, Kunimitsu
AU  - Iwai K
FAU - Sumino, Hiroyuki
AU  - Sumino H
FAU - Yamaguchi, Nobuo
AU  - Yamaguchi N
FAU - Kanda, Tsugiyasu
AU  - Kanda T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080304
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (bu-zhong-yi-qi-tang)
SB  - IM
MH  - Animals
MH  - *Atrophy/drug therapy/pathology
MH  - Behavior, Animal/drug effects
MH  - Body Temperature
MH  - Body Weight
MH  - Brain/anatomy & histology/*drug effects/*pathology
MH  - *Brain Diseases/drug therapy/pathology
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Brucella abortus
MH  - *Drugs, Chinese Herbal/pharmacology/therapeutic use
MH  - Eating
MH  - *Fatigue Syndrome, Chronic/drug therapy/pathology
MH  - Female
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Motor Activity/drug effects
MH  - Random Allocation
MH  - Survival Rate
EDAT- 2008/03/05 09:00
MHDA- 2008/11/01 09:00
CRDT- 2008/03/05 09:00
PHST- 2007/11/14 00:00 [received]
PHST- 2008/01/31 00:00 [accepted]
PHST- 2008/03/05 09:00 [pubmed]
PHST- 2008/11/01 09:00 [medline]
PHST- 2008/03/05 09:00 [entrez]
AID - 10.1007/s11064-008-9620-1 [doi]
PST - ppublish
SO  - Neurochem Res. 2008 Sep;33(9):1759-67. doi: 10.1007/s11064-008-9620-1. Epub 2008 
      Mar 4.