PMID- 18320241
OWN - NLM
STAT- MEDLINE
DCOM- 20080930
LR  - 20211020
IS  - 0949-8257 (Print)
IS  - 0949-8257 (Linking)
VI  - 13
IP  - 5
DP  - 2008 Jun
TI  - Cleavage agents for soluble oligomers of human islet amyloid polypeptide.
PG  - 693-701
LID - 10.1007/s00775-008-0354-y [doi]
AB  - Soluble oligomers of human islet amyloid polypeptide (h-IAPP) are implicated in 
      the initiation of beta-cell apoptosis leading to type 2 diabetes mellitus (T2DM). 
      Cleavage of the h-IAPP included in an oligomer may provide a novel method for 
      reducing the level of h-IAPP oligomers, offering a new therapeutic option for 
      T2DM. From the combinatorial library of triazine derivatives prepared by 
      exploiting the Co(III) complex of cyclen as the cleavage center for peptide 
      bonds, eight compounds were selected as cleavage agents for oligomers of h-IAPP. 
      After reaction with cleavage agents for 36 h at 37 degrees C and pH 7.50, up to 
      20 mol% of h-IAPP (initial concentration: 4.0 microM) was cleaved, although the 
      target oligomers existed as transient species. Considerable activity was 
      manifested at agent concentrations as low as 100 nM.
FAU - Suh, Junghun
AU  - Suh J
AD  - Department of Chemistry, Seoul National University, Seoul, 151-747, South Korea. 
      jhsuh@snu.ac.kr
FAU - Chei, Woo Suk
AU  - Chei WS
FAU - Lee, Tae Yeon
AU  - Lee TY
FAU - Kim, Min Gyum
AU  - Kim MG
FAU - Yoo, Sang Ho
AU  - Yoo SH
FAU - Jeong, Keunhong
AU  - Jeong K
FAU - Ahn, Jae Young
AU  - Ahn JY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080305
PL  - Germany
TA  - J Biol Inorg Chem
JT  - Journal of biological inorganic chemistry : JBIC : a publication of the Society 
      of Biological Inorganic Chemistry
JID - 9616326
RN  - 0 (Amyloid)
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Indicators and Reagents)
RN  - 0 (Islet Amyloid Polypeptide)
RN  - 0 (Peptide Fragments)
RN  - 0 (Triazines)
RN  - 0 (amyloid beta-protein (1-42))
SB  - IM
MH  - Amyloid/*chemistry
MH  - Amyloid beta-Peptides/chemistry
MH  - Combinatorial Chemistry Techniques
MH  - Filtration
MH  - Hydrogen-Ion Concentration
MH  - Hydrolysis
MH  - Indicators and Reagents
MH  - Islet Amyloid Polypeptide
MH  - Isomerism
MH  - Peptide Fragments/chemistry
MH  - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
MH  - Triazines/chemical synthesis/pharmacology
EDAT- 2008/03/06 09:00
MHDA- 2008/10/01 09:00
CRDT- 2008/03/06 09:00
PHST- 2007/12/16 00:00 [received]
PHST- 2008/02/07 00:00 [accepted]
PHST- 2008/03/06 09:00 [pubmed]
PHST- 2008/10/01 09:00 [medline]
PHST- 2008/03/06 09:00 [entrez]
AID - 10.1007/s00775-008-0354-y [doi]
PST - ppublish
SO  - J Biol Inorg Chem. 2008 Jun;13(5):693-701. doi: 10.1007/s00775-008-0354-y. Epub 
      2008 Mar 5.