PMID- 18320495
OWN - NLM
STAT- MEDLINE
DCOM- 20080328
LR  - 20090407
IS  - 1438-8790 (Electronic)
IS  - 0934-8387 (Linking)
VI  - 62
IP  - 3
DP  - 2008 Mar
TI  - [Trial end-point in chronic obstructive pulmonary disease (COPD): minimal 
      clinically important difference].
PG  - 149-55
LID - 10.1055/s-2007-996182 [doi]
AB  - The concept of the minimal clinically important difference (MCID) is intended to 
      provide a measure of relevance for a statistically applied in patients with COPD. 
      Clinically important differences are those differences relevant to the individual 
      patient and important to the patient's life. However, people's difference in a 
      diagnostic parameter perception of what is important vary. Furthermore, 
      physicians may rate the significance of a particular marker and its difference 
      which can be achieved by a pharmacological intervention differently from the 
      patient. Thus, the major problem with defining an MCID for any measure is that 
      the most important differences, which require the most subtle measures for an 
      individual patient, are likely to have the least general application. Conversely, 
      measures that can be generalised are unlikely to have much individual importance 
      and will be very crude tools for an individual assessment. In medical trials 
      both, statistical rigor and clinical relevance are generally required, and MCID 
      is without doubt a key application tool defining treatment success or treatment 
      failure. This paper gives an update on the concept of a minimal important 
      difference of most relevant parameters in COPD treatment.
FAU - Gillissen, A
AU  - Gillissen A
AD  - Robert Koch-Klinik, Thoraxzentrum des Klinikums St. Georg Leipzig.
FAU - Buhl, R
AU  - Buhl R
FAU - Kardos, P
AU  - Kardos P
FAU - Puhan, M
AU  - Puhan M
FAU - Rabe, K F
AU  - Rabe KF
FAU - Rothe, T
AU  - Rothe T
FAU - Sauer, R
AU  - Sauer R
FAU - Welte, T
AU  - Welte T
FAU - Worth, H
AU  - Worth H
FAU - Menz, G
AU  - Menz G
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Studienendpunkte bei der chronisch-obstruktiven Lungenerkrankung (COPD): "Minimal 
      Clinically Important Difference".
PL  - Germany
TA  - Pneumologie
JT  - Pneumologie (Stuttgart, Germany)
JID - 8906641
SB  - IM
MH  - Clinical Trials as Topic
MH  - Humans
MH  - Pulmonary Disease, Chronic Obstructive/*physiopathology/*therapy
MH  - Quality of Life
MH  - Treatment Outcome
RF  - 118
EDAT- 2008/03/06 09:00
MHDA- 2008/03/29 09:00
CRDT- 2008/03/06 09:00
PHST- 2008/03/06 09:00 [pubmed]
PHST- 2008/03/29 09:00 [medline]
PHST- 2008/03/06 09:00 [entrez]
AID - 10.1055/s-2007-996182 [doi]
PST - ppublish
SO  - Pneumologie. 2008 Mar;62(3):149-55. doi: 10.1055/s-2007-996182.