PMID- 18320516
OWN - NLM
STAT- MEDLINE
DCOM- 20080603
LR  - 20190917
IS  - 1120-6721 (Print)
IS  - 1120-6721 (Linking)
VI  - 18
IP  - 2
DP  - 2008 Mar-Apr
TI  - Atherosclerotic and thrombophilic risk factors in patients with recurrent central 
      retinal vein occlusion.
PG  - 233-8
AB  - PURPOSE: Atherosclerotic and thrombophilic risk factors may be causes of central 
      retinal vein occlusion (CRVO). The aim of this study was to evaluate the 
      prevalence of the aforesaid risk factors in patients with recurrent CRVOs and 
      patients with a single episode of CRVO. METHODS: Seventeen patients with 
      recurrent CRVO and 30 with a single episode of CRVO were enrolled. The 
      atherosclerotic risk factors investigated were hypertension, diabetes, smoking, 
      and dyslipidemia. Specific laboratory tests for the following thrombophilic 
      markers were performed: homocystinemia (Hcy), lipoprotein (a), factor VIII, 
      factor II G20210A and factor V G1691A polymorphisms, lupus anticoagulant, 
      anticardiolipin antibodies, plasminogen activator inhibitor-1, and deficit of 
      vitamins B6, B12, and folic acid. A multivariate analysis, adjusted for age, 
      gender, traditional and thrombophilic risk factors, was performed. Statistical 
      significance was set at p<or=0.05. RESULTS: Hypercholesterolemia, 
      hypertriglyceridemia, fasting, and postmethionine hyperhomocysteinemia (HHcy) 
      were more prevalent in recurrent CRVO patients (p<0.001, p<0.001, p=0.006, and 
      p=0.005, respectively). At multivariate analysis, hypercholesterolemia (OR: 5.04, 
      95% CI 1.39-18.17; p=0.025), hypertriglyceridemia (OR: 5.60, 95% CI 1.52-20.61; 
      p=0.017), fasting HHcy (OR: 5.77, 95% CI 1.39-23.89; p=0.028), and postmethionine 
      HHcy (OR: 10.88, 95% CI 2.50-47.42; p=0.002) were found to be significantly 
      associated with recurrent CRVO. CONCLUSIONS: Dyslipidemia and 
      hyperhomocysteinemia are independent risk factors for the occurrence of recurrent 
      CRVO. A complete assessment of atherosclerotic and thrombophilic risk factors in 
      CRVO patients. In addition, the need for a specific treatment is suggested.
FAU - Sodi, A
AU  - Sodi A
AD  - Department of Oto-Neuro-Ophthalmological Surgical Sciences, Eye Clinic, Firenze, 
      Italy.
FAU - Giambene, B
AU  - Giambene B
FAU - Marcucci, R
AU  - Marcucci R
FAU - Sofi, F
AU  - Sofi F
FAU - Bolli, P
AU  - Bolli P
FAU - Abbate, R
AU  - Abbate R
FAU - Prisco, D
AU  - Prisco D
FAU - Menchini, U
AU  - Menchini U
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Eur J Ophthalmol
JT  - European journal of ophthalmology
JID - 9110772
RN  - 0 (Biomarkers)
SB  - IM
MH  - Aged
MH  - Atherosclerosis/*complications/diagnosis
MH  - Biomarkers/analysis
MH  - Chromatography, High Pressure Liquid
MH  - Dyslipidemias/*complications/diagnosis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Hyperhomocysteinemia/*complications/diagnosis
MH  - Male
MH  - Prevalence
MH  - Radioimmunoassay
MH  - Recurrence
MH  - Retinal Vein Occlusion/*etiology
MH  - Risk Factors
MH  - Thrombophilia/*complications/diagnosis
EDAT- 2008/03/06 09:00
MHDA- 2008/06/05 09:00
CRDT- 2008/03/06 09:00
PHST- 2008/03/06 09:00 [pubmed]
PHST- 2008/06/05 09:00 [medline]
PHST- 2008/03/06 09:00 [entrez]
AID - 10.1177/112067210801800211 [doi]
PST - ppublish
SO  - Eur J Ophthalmol. 2008 Mar-Apr;18(2):233-8. doi: 10.1177/112067210801800211.