PMID- 18320714
OWN - NLM
STAT- MEDLINE
DCOM- 20080409
LR  - 20231208
IS  - 0065-1400 (Print)
IS  - 0065-1400 (Linking)
VI  - 67
IP  - 4
DP  - 2007
TI  - Human cord blood cells can differentiate into retinal nerve cells.
PG  - 359-65
LID - 1653 [pii]
LID - 10.55782/ane-2007-1653 [doi]
AB  - Retinal degeneration and dystrophy are the major causes of blindness in the 
      developed world. It has been reported that human cord blood cells (HCBCs) can 
      differentiate into neuron-like cells in vitro. We have recently demonstrated that 
      bone marrow cells (BMCs) of both mice and rats can differentiate into retinal 
      nerve cells (RNCs). In the present study, we show the differentiation capacity of 
      HCBCs into RNCs in vivo. We transplanted lineage-negative HCBCs into the 
      subretinal space of severe combined immunodeficiency (SCID) mice. Two weeks after 
      the transplantation, some of the transplanted cells expressed human nestin, human 
      MAP2, human neuron specific enolase (NSE), beta-III tubulin and also rhodopsin. 
      These results indicate that HCBCs can differentiate into RNCs and suggest that 
      our new strategy could be used for the regeneration of retinal nerve cells in 
      degenerative or dystrophic diseases.
FAU - Koike-Kiriyama, Naoko
AU  - Koike-Kiriyama N
AD  - First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka 
      570-8506, Japan.
FAU - Adachi, Yasushi
AU  - Adachi Y
FAU - Minamino, Keizo
AU  - Minamino K
FAU - Iwasaki, Masayoshi
AU  - Iwasaki M
FAU - Nakano, Keiji
AU  - Nakano K
FAU - Koike, Yasushi
AU  - Koike Y
FAU - Yamada, Haruhiko
AU  - Yamada H
FAU - Mukaide, Hiromi
AU  - Mukaide H
FAU - Shigematsu, Akio
AU  - Shigematsu A
FAU - Mizokami, Tomomi
AU  - Mizokami T
FAU - Matsumura, Miyo
AU  - Matsumura M
FAU - Ikehara, Susumu
AU  - Ikehara S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - Acta Neurobiol Exp (Wars)
JT  - Acta neurobiologiae experimentalis
JID - 1246675
RN  - 0 (Biomarkers)
RN  - 9009-81-8 (Rhodopsin)
RN  - EC 1.2.1.- (Glyceraldehyde-3-Phosphate Dehydrogenases)
SB  - IM
MH  - Animals
MH  - Biomarkers
MH  - Cell Differentiation/physiology
MH  - Cell Lineage/physiology
MH  - *Cord Blood Stem Cell Transplantation
MH  - Fetal Blood/*cytology
MH  - Glyceraldehyde-3-Phosphate Dehydrogenases/genetics
MH  - Hematopoietic Stem Cells/*cytology
MH  - Humans
MH  - Mice
MH  - Mice, SCID
MH  - Neurons, Afferent/*cytology
MH  - Retina/*cytology
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Rhodopsin/genetics
EDAT- 2008/03/07 09:00
MHDA- 2008/04/10 09:00
CRDT- 2008/03/07 09:00
PHST- 2008/03/07 09:00 [pubmed]
PHST- 2008/04/10 09:00 [medline]
PHST- 2008/03/07 09:00 [entrez]
AID - 1653 [pii]
AID - 10.55782/ane-2007-1653 [doi]
PST - ppublish
SO  - Acta Neurobiol Exp (Wars). 2007;67(4):359-65. doi: 10.55782/ane-2007-1653.