PMID- 18322308
OWN - NLM
STAT- MEDLINE
DCOM- 20090129
LR  - 20220318
IS  - 1735-1502 (Print)
IS  - 1735-1502 (Linking)
VI  - 7
IP  - 1
DP  - 2008 Mar
TI  - Determination of HLA-B27 subtypes in Iranian patients with ankylosing 
      spondylitis.
PG  - 19-24
AB  - The human leukocyte antigen-B27 is one of the class I molecules of the major 
      histocompatibility complex which is strongly associated with ankylosing 
      spondylitis (AS). The strength of the disease association with B27 varies 
      markedly among racial and ethnic populations. It is an allele family, which 
      constitutes about 31 subtypes, with a considerable geographic and ethnic 
      difference in distribution. It is important to know whether certain subtypes show 
      any preferential association with AS. Because there is no report regarding 
      HLA-B27 subtypes in Iranian patients with AS, the main purpose of the present 
      study was to assess the frequency of subtypes of human leukocyte antigen 
      (HLA)-B27 in patients with ankylosing spondylitis in Iranian populationOne 
      hundred and nineteen AS patients (82 HLA-B27 positive and 37 HLA-B27 negative) 
      were selected for this study. HLA-B27 positive patients were screened by 
      polymerase chain reaction amplification with sequence-specific primers (PCR-SSP) 
      for B*27 subtyping.The results of present study revealed that only two subtypes 
      were detected in Iranian patients, including B*2705 (52 patients, 63.4%) and 
      B*2702 (30 patients, 36.6%). Our results showed a restricted number of HLA-B27 
      subtypes associated with AS in Iran and an elevated frequency of the B*2705 
      allele in these patients similar to other Euro-Caucasoid (Aryan) groups in the 
      world.
FAU - Nicknam, Mohamad Hossein
AU  - Nicknam MH
AD  - Molecular Immunology Research Center, Faculty of Medicine, Medical Sciences/ 
      University of Tehran, Tehran, Iran. nicknam_m@yahoo.com
FAU - Mahmoudi, Mahdi
AU  - Mahmoudi M
FAU - Amirzargar, Ali Akbar
AU  - Amirzargar AA
FAU - Ganjalikhani Hakemi, Mazdak
AU  - Ganjalikhani Hakemi M
FAU - Khosravi, Farideh
AU  - Khosravi F
FAU - Jamshidi, Ahmad Reza
AU  - Jamshidi AR
FAU - Amirkhani, Aref
AU  - Amirkhani A
FAU - Ansaripour, Bita
AU  - Ansaripour B
FAU - Pourpak, Zahra
AU  - Pourpak Z
FAU - Moin, Mostafa
AU  - Moin M
FAU - Nikbin, Behrooz
AU  - Nikbin B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Iran
TA  - Iran J Allergy Asthma Immunol
JT  - Iranian journal of allergy, asthma, and immunology
JID - 101146178
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B*27:05 antigen)
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-B Antigens/biosynthesis/*genetics/immunology
MH  - HLA-B27 Antigen/biosynthesis/*genetics/immunology
MH  - Humans
MH  - Iran
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Spondylitis, Ankylosing/epidemiology/*genetics/immunology
EDAT- 2008/03/07 09:00
MHDA- 2009/01/30 09:00
CRDT- 2008/03/07 09:00
PHST- 2008/03/07 09:00 [pubmed]
PHST- 2009/01/30 09:00 [medline]
PHST- 2008/03/07 09:00 [entrez]
AID - 07011924 [pii]
PST - ppublish
SO  - Iran J Allergy Asthma Immunol. 2008 Mar;7(1):19-24.