PMID- 18322987
OWN - NLM
STAT- MEDLINE
DCOM- 20080715
LR  - 20151119
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
VI  - 35
IP  - 4
DP  - 2008 Apr
TI  - Minimal clinically important difference for 7 measures of fatigue in patients 
      with systemic lupus erythematosus.
PG  - 635-42
AB  - OBJECTIVE: To determine the minimal clinically important difference (MCID) for 7 
      measures of fatigue in patients with systemic lupus erythematosus (SLE). METHODS: 
      Study subjects completed 7 fatigue instruments [Fatigue Severity Scale (FSS), 
      Multidimensional Assessment of Fatigue (MAF), Multidimensional Fatigue Inventory 
      (MFI), Vitality scale of the MOS-SF-36, Chalder Fatigue Scale (CFS), Functional 
      Assessment of Chronic Illness Therapy-Fatigue, and a global Rating Scale (RS)] 
      and then participated in a series of interviews with other study participants 
      comparing their fatigue with one another. Each interview participant rated the 
      difference in their fatigue levels on a 7-point transition scale. The MCID was 
      estimated from the mean difference in fatigue scores between each pair of 
      interview participants based on their subjective rating of fatigue contrast. The 
      MCID was also estimated using linear regression modeling. RESULTS: Eighty 
      patients with SLE participated. Patients reported significant levels of fatigue 
      [mean normalized (0 = none, 100 = maximum) fatigue scores for the 7 instruments 
      ranged from 49.8 (CFS) to 71.1 (FSS)]. The MCID of "a little more" fatigue tended 
      to be greater than the MCID for a "little less fatigue" and differed 
      significantly for FSS and MAF. The MCID of normalized scores estimated by linear 
      regression ranged from 7.0 (CFS) to 14.3 (MFI). CONCLUSION: Fatigue is a common 
      and debilitating component of SLE. Estimates of MCID will help to interpret 
      changes observed in a fatigue score and will be critical in estimating sample 
      size requirements for clinical trials including fatigue as an outcome.
FAU - Goligher, Ewan C
AU  - Goligher EC
AD  - Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital 
      and Harvard Medical School, Boston, Massachusetts, USA.
FAU - Pouchot, Jacques
AU  - Pouchot J
FAU - Brant, Rollin
AU  - Brant R
FAU - Kherani, Raheem B
AU  - Kherani RB
FAU - Avina-Zubieta, J Antonio
AU  - Avina-Zubieta JA
FAU - Lacaille, Diane
AU  - Lacaille D
FAU - Lehman, Allen J
AU  - Lehman AJ
FAU - Ensworth, Stephanie
AU  - Ensworth S
FAU - Kopec, Jacek
AU  - Kopec J
FAU - Esdaile, John M
AU  - Esdaile JM
FAU - Liang, Matthew H
AU  - Liang MH
LA  - eng
GR  - AR47782/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080301
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Data Interpretation, Statistical
MH  - Disability Evaluation
MH  - Fatigue/*diagnosis/etiology/psychology
MH  - Female
MH  - *Health Status Indicators
MH  - Humans
MH  - Lupus Erythematosus, Systemic/complications/*diagnosis/psychology
MH  - Male
MH  - Middle Aged
MH  - Quality of Life
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
EDAT- 2008/03/07 09:00
MHDA- 2008/07/17 09:00
CRDT- 2008/03/07 09:00
PHST- 2008/03/07 09:00 [pubmed]
PHST- 2008/07/17 09:00 [medline]
PHST- 2008/03/07 09:00 [entrez]
AID - 08/13/039 [pii]
PST - ppublish
SO  - J Rheumatol. 2008 Apr;35(4):635-42. Epub 2008 Mar 1.